Department of Fixed & Implant Prosthodontics, School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki 541 24, Greece.
Department of Biomaterials, School of Dentistry, National and Kapodistrian University of Athens, Athens, 115 27, Greece.
Int J Mol Sci. 2009 Sep 4;10(9):3861-3899. doi: 10.3390/ijms10093861.
Resin-based dental restorative materials are extensively used today in dentistry. However, significant concerns still remain regarding their biocompatibility. For this reason, significant scientific effort has been focused on the determination of the molecular toxicology of substances released by these biomaterials, using several tools for risk assessment, including exposure assessment, hazard identification and dose-response analysis. These studies have shown that substances released by these materials can cause significant cytotoxic and genotoxic effects, leading to irreversible disturbance of basic cellular functions. The aim of this article is to review current knowledge related to dental composites' molecular toxicology and to give implications for possible improvements concerning their biocompatibility.
如今，树脂基牙科修复材料在牙科领域得到了广泛应用。然而，人们对其生物相容性仍存在重大担忧。出于这个原因，科学界投入了大量精力来确定这些生物材料释放的物质的分子毒理学，使用了几种风险评估工具，包括暴露评估、危害识别和剂量-反应分析。这些研究表明，这些材料释放的物质会引起明显的细胞毒性和遗传毒性作用，导致基本细胞功能的不可逆紊乱。本文旨在综述牙科复合材料分子毒理学的现有知识，并对提高其生物相容性提出可能的改进建议。
