Institute of Clinical Chemistry, Faculty of Medicine, Campus Grosshadern, Ludwig-Maximilians-University of Munich, Marchioninistrasse 15, 81377 Munich, Germany.
Dent Mater. 2010 Jan;26(1):91-9. doi: 10.1016/j.dental.2009.08.014.
Components released from resin-based dental materials are important factors in the assessment of the biocompatibility of these materials. The study was performed to investigate the elution of substances from unpolymerized and polymerized composites (Tetric=TET; Arabesk=ARA), ormoceres (Admira)=ADM; Definite=DEF) and the compomere (Hytac=HYT).
Specimens were polymerized and immersed in either water or methanol. Besides the unpolymerized specimens were dissolved in methanol. Eluted substances were detected by gas chromatography/mass spectroscopy. The Nernst partition coefficient (DC) of 64 substances, eluted from various resin-based dental materials was determined.
Only in methanolic and aqueous eluates from unpolymerized and polymerized specimens of DEF and ADM, the comonomere 1,2/1,3-glycerol dimethacrylate was measured. Triethylene glycol dimethacrylate was eluted into the aqueous and methanolic phase from polymerized specimens from TET and ARA. 2-Hydroxyethyl methacrylate was eluted into the methanolic phase from polymerized specimen from TET and HYT. Residuals of monomer synthesis like triphenyl stibane were found in unpolymerized specimens of TET and ARA. Camphorquinone was eluted into the methanolic eluate from polymerized and unpolymerized specimens from all tested dental materials. Highest DC of 20.8 was found for 1/2-cyclohexene methacrylate. DC of urethane dimethacrylate and bisphenol-A-glycidyldimethacrylate varies from different manufacturers.
Impurities from manufacturing process were found in some resin-based materials. Various well-known substances causing allergic reactions were found in aqueous or methanolic elutes. Patients, dental and manufacturing personnel are exposed to these substances.
从树脂基牙科材料中释放的成分是评估这些材料生物相容性的重要因素。本研究旨在研究未聚合和聚合复合材料（Tetric=TET；Arabesk=ARA）、有机玻璃（Admira）=ADM；Definite=DEF）和 compomere（Hytac=HYT）的物质浸出情况。
将样本聚合并浸入水或甲醇中。此外，未聚合的样本溶解在甲醇中。通过气相色谱/质谱法检测洗脱的物质。测定了从各种树脂基牙科材料中洗脱的 64 种物质的 Nernst 分配系数（DC）。
仅在 DEF 和 ADM 的未聚合和聚合标本的甲醇和水性洗脱液中，检测到了共聚单体 1,2/1,3-甘油二甲基丙烯酸酯。三乙二醇二甲基丙烯酸酯从 TET 和 ARA 的聚合标本中洗脱到水性和甲醇相中。2-羟乙基甲基丙烯酸酯从 TET 和 HYT 的聚合标本中洗脱到甲醇相中。在 TET 和 ARA 的未聚合标本中发现了单体合成的残留物，如三苯基锑。樟脑醌从所有测试的牙科材料的聚合和未聚合标本中洗脱到甲醇洗脱液中。1/2-环己烯甲基丙烯酸酯的 DC 最高为 20.8。聚氨酯二甲基丙烯酸酯和双酚 A-缩水甘油二甲基丙烯酸酯的 DC 因制造商而异。
在一些树脂基材料中发现了制造过程中的杂质。在水性或甲醇洗脱液中发现了各种已知的引起过敏反应的物质。患者、牙科和制造人员都接触到这些物质。
