在不对称催化中使用5,5-（二甲基）-异丙基-PHOX作为叔丁基-PHOX的实际等效物。
Use of 5,5-(dimethyl)-i-Pr-PHOX as a practical equivalent to t-Bu-PHOX in asymmetric catalysis.
作者信息
Bélanger Etienne, Pouliot Marie-France, Paquin Jean-François
机构信息
Organic and Medicinal Chemistry, Département de chimie, Université Laval, Québec, QC, Canada G1V 0A6.
出版信息
Org Lett. 2009 May 21;11(10):2201-4. doi: 10.1021/ol9005618.
PMID:19388656
Abstract
The use of 5,5-(dimethyl)-i-Pr-PHOX as a practical equivalent of t-Bu-PHOX in asymmetric catalysis is reported. This new member of the phosphinooxazoline (PHOX) ligand family behaves similarly in terms of stereoinduction to t-Bu-PHOX with the key advantage of being readily accessible as both enantiomers starting from either (S)- or (R)-valine.
摘要
据报道，5,5-（二甲基）-异丙基-PHOX在不对称催化中可作为叔丁基-PHOX的实际等效物使用。磷酰恶唑啉（PHOX）配体家族的这个新成员在立体诱导方面与叔丁基-PHOX表现相似，其关键优势在于从（S）-或（R）-缬氨酸开始，两种对映体都易于获得。
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