Jacquemet Vincent, Henriquez Craig S
Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
IEEE Trans Biomed Eng. 2009 Mar;56(3):893-6. doi: 10.1109/TBME.2008.2006028.
This paper explores the conditions under which nonmyocytes, when electrically coupled to myocytes, act as a passive load during the depolarization phase. Using theoretical arguments and numerical simulations in a tissue incorporating fibroblasts, the passive load approximation is shown to be accurate at low coupling conductances (< 2 nS). In this case, the effect on conduction velocity can be expressed as a function of the elevation in resting potential and the coupling only.
本文探讨了非心肌细胞在与心肌细胞电耦合时,在去极化阶段作为被动负载的条件。通过在包含成纤维细胞的组织中运用理论论证和数值模拟,结果表明在低耦合电导(<2 nS)时,被动负载近似是准确的。在这种情况下,对传导速度的影响可以仅表示为静息电位升高和耦合的函数。