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同种异体间充质干细胞移植治疗多发性硬化症。

Allogeneic mesenchymal stem cells transplantation in treatment of multiple sclerosis.

作者信息

Liang J, Zhang H, Hua B, Wang H, Wang J, Han Z, Sun L

机构信息

Department of Immunology and Rheumatology, Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, P. R. China.

出版信息

Mult Scler. 2009 May;15(5):644-6. doi: 10.1177/1352458509104590.

DOI:10.1177/1352458509104590
PMID:19389752
Abstract

Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system. Umbilical cord derived mesenchymal stem cells are immunosuppressive. We transplanted mesenchymal stem cells in a patient with refractory progressive MS, and the disease course was stabilized after the transplantation. We postulate that mesenchymal stem cells have a potent immunosuppressive effect in vivo.

摘要

多发性硬化症(MS)是一种中枢神经系统的慢性自身免疫性疾病。脐带间充质干细胞具有免疫抑制作用。我们对一名难治性进展型MS患者进行了间充质干细胞移植,移植后疾病进程得到稳定。我们推测间充质干细胞在体内具有强大的免疫抑制作用。

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Allogeneic mesenchymal stem cells transplantation in treatment of multiple sclerosis.同种异体间充质干细胞移植治疗多发性硬化症。
Mult Scler. 2009 May;15(5):644-6. doi: 10.1177/1352458509104590.
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Continued disease activity in a patient with multiple sclerosis after allogeneic hematopoietic cell transplantation.异基因造血细胞移植后多发性硬化症患者疾病活动持续存在。
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Transplantation of mesenchymal stem cells enhances axonal outgrowth and cell survival in an organotypic spinal cord slice culture.间充质干细胞移植可促进器官型脊髓切片培养中的轴突生长和细胞存活。
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Human Umbilical Cord-Derived Mesenchymal Stem Cells in the Treatment of Multiple Sclerosis Patients: Phase I/II Dose-Finding Clinical Study.人脐带间充质干细胞治疗多发性硬化症患者的 I/II 期剂量探索临床研究。
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Syngeneic Mesenchymal Stem Cells Reduce Immune Rejection After Induced Pluripotent Stem Cell-Derived Allogeneic Cardiomyocyte Transplantation.同种异体间充质干细胞减少诱导多能干细胞源性同种异体心肌细胞移植后的免疫排斥反应。
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