Cavanaugh Kerri L, Wingard Rebecca L, Hakim Raymond M, Elasy Tom A, Ikizler T Alp
Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2372, USA.
Clin J Am Soc Nephrol. 2009 May;4(5):950-6. doi: 10.2215/CJN.04580908. Epub 2009 Apr 23.
Patient knowledge about chronic hemodialysis (CHD) is important for effective self-management behaviors, but little is known about its association with vascular access use.
DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Prospective cohort of adult incident CHD patients from May 2002 until November 2005 and followed for 6 mo after initiation of hemodialysis (HD). Patient knowledge was measured using the Chronic Hemodialysis Knowledge Survey (CHeKS). The primary outcome was dialysis access type at: baseline, 3 mo, and 6 mo after HD initiation. Secondary outcomes included anemia, nutritional, and mineral laboratory measures.
In 490 patients, the median (interquartile range) CHeKS score (0 to 100%) was 65%[52% to 78%]. Lower scores were associated with older age, fewer years of education, and nonwhite race. Patients with CHeKS scores 20 percentage points higher were more likely to use an arteriovenous fistula or graft compared with a catheter at HD initiation and 6 mo after adjustment for age, sex, race, education, and diabetes mellitus. No statistically significant associations were found between knowledge and laboratory outcome measures, except for a moderate association with serum albumin. Potential limitations include residual confounding and an underpowered study to determine associations with some clinical measures.
Patients with less dialysis knowledge may be less likely to use an arteriovenous access for dialysis at initiation and after starting hemodialysis. Additional studies are needed to explore the impact of patient dialysis knowledge, and its improvement after educational interventions, on vascular access in hemodialysis.
患者对慢性血液透析(CHD)的了解对于有效的自我管理行为很重要,但关于其与血管通路使用之间的关联却知之甚少。
设计、地点、参与者与测量方法:对2002年5月至2005年11月期间新确诊的成年CHD患者进行前瞻性队列研究,并在开始血液透析(HD)后随访6个月。使用慢性血液透析知识调查(CHeKS)来测量患者的知识水平。主要结局是HD开始时、3个月和6个月时的透析通路类型。次要结局包括贫血、营养和矿物质实验室指标。
在490名患者中,CHeKS评分(0至100%)的中位数(四分位间距)为65%[52%至78%]。较低的评分与年龄较大、受教育年限较少和非白人种族相关。在调整年龄、性别、种族、教育程度和糖尿病后,CHeKS评分高20个百分点的患者在HD开始时和6个月时比使用导管的患者更有可能使用动静脉内瘘或移植物。除了与血清白蛋白有中度关联外,未发现知识与实验室结局指标之间存在统计学上的显著关联。潜在的局限性包括残余混杂因素以及一项确定与某些临床指标关联的研究效能不足。
透析知识较少的患者在开始透析时和开始血液透析后使用动静脉通路进行透析的可能性可能较小。需要进一步研究来探讨患者透析知识及其在教育干预后的改善对血液透析血管通路的影响。