普通牛的基因组序列：反刍动物生物学与进化的一扇窗口。

The genome sequence of taurine cattle: a window to ruminant biology and evolution.

作者信息

Elsik Christine G, Tellam Ross L, Worley Kim C, Gibbs Richard A, Muzny Donna M, Weinstock George M, Adelson David L, Eichler Evan E, Elnitski Laura, Guigó Roderic, Hamernik Debora L, Kappes Steve M, Lewin Harris A, Lynn David J, Nicholas Frank W, Reymond Alexandre, Rijnkels Monique, Skow Loren C, Zdobnov Evgeny M, Schook Lawrence, Womack James, Alioto Tyler, Antonarakis Stylianos E, Astashyn Alex, Chapple Charles E, Chen Hsiu-Chuan, Chrast Jacqueline, Câmara Francisco, Ermolaeva Olga, Henrichsen Charlotte N, Hlavina Wratko, Kapustin Yuri, Kiryutin Boris, Kitts Paul, Kokocinski Felix, Landrum Melissa, Maglott Donna, Pruitt Kim, Sapojnikov Victor, Searle Stephen M, Solovyev Victor, Souvorov Alexandre, Ucla Catherine, Wyss Carine, Anzola Juan M, Gerlach Daniel, Elhaik Eran, Graur Dan, Reese Justin T, Edgar Robert C, McEwan John C, Payne Gemma M, Raison Joy M, Junier Thomas, Kriventseva Evgenia V, Eyras Eduardo, Plass Mireya, Donthu Ravikiran, Larkin Denis M, Reecy James, Yang Mary Q, Chen Lin, Cheng Ze, Chitko-McKown Carol G, Liu George E, Matukumalli Lakshmi K, Song Jiuzhou, Zhu Bin, Bradley Daniel G, Brinkman Fiona S L, Lau Lilian P L, Whiteside Matthew D, Walker Angela, Wheeler Thomas T, Casey Theresa, German J Bruce, Lemay Danielle G, Maqbool Nauman J, Molenaar Adrian J, Seo Seongwon, Stothard Paul, Baldwin Cynthia L, Baxter Rebecca, Brinkmeyer-Langford Candice L, Brown Wendy C, Childers Christopher P, Connelley Timothy, Ellis Shirley A, Fritz Krista, Glass Elizabeth J, Herzig Carolyn T A, Iivanainen Antti, Lahmers Kevin K, Bennett Anna K, Dickens C Michael, Gilbert James G R, Hagen Darren E, Salih Hanni, Aerts Jan, Caetano Alexandre R, Dalrymple Brian, Garcia Jose Fernando, Gill Clare A, Hiendleder Stefan G, Memili Erdogan, Spurlock Diane, Williams John L, Alexander Lee, Brownstein Michael J, Guan Leluo, Holt Robert A, Jones Steven J M, Marra Marco A, Moore Richard, Moore Stephen S, Roberts Andy, Taniguchi Masaaki, Waterman Richard C, Chacko Joseph, Chandrabose Mimi M, Cree Andy, Dao Marvin Diep, Dinh Huyen H, Gabisi Ramatu Ayiesha, Hines Sandra, Hume Jennifer, Jhangiani Shalini N, Joshi Vandita, Kovar Christie L, Lewis Lora R, Liu Yih-Shin, Lopez John, Morgan Margaret B, Nguyen Ngoc Bich, Okwuonu Geoffrey O, Ruiz San Juana, Santibanez Jireh, Wright Rita A, Buhay Christian, Ding Yan, Dugan-Rocha Shannon, Herdandez Judith, Holder Michael, Sabo Aniko, Egan Amy, Goodell Jason, Wilczek-Boney Katarzyna, Fowler Gerald R, Hitchens Matthew Edward, Lozado Ryan J, Moen Charles, Steffen David, Warren James T, Zhang Jingkun, Chiu Readman, Schein Jacqueline E, Durbin K James, Havlak Paul, Jiang Huaiyang, Liu Yue, Qin Xiang, Ren Yanru, Shen Yufeng, Song Henry, Bell Stephanie Nicole, Davis Clay, Johnson Angela Jolivet, Lee Sandra, Nazareth Lynne V, Patel Bella Mayurkumar, Pu Ling-Ling, Vattathil Selina, Williams Rex Lee, Curry Stacey, Hamilton Cerissa, Sodergren Erica, Wheeler David A, Barris Wes, Bennett Gary L, Eggen André, Green Ronnie D, Harhay Gregory P, Hobbs Matthew, Jann Oliver, Keele John W, Kent Matthew P, Lien Sigbjørn, McKay Stephanie D, McWilliam Sean, Ratnakumar Abhirami, Schnabel Robert D, Smith Timothy, Snelling Warren M, Sonstegard Tad S, Stone Roger T, Sugimoto Yoshikazu, Takasuga Akiko, Taylor Jeremy F, Van Tassell Curtis P, Macneil Michael D, Abatepaulo Antonio R R, Abbey Colette A, Ahola Virpi, Almeida Iassudara G, Amadio Ariel F, Anatriello Elen, Bahadue Suria M, Biase Fernando H, Boldt Clayton R, Carroll Jeffery A, Carvalho Wanessa A, Cervelatti Eliane P, Chacko Elsa, Chapin Jennifer E, Cheng Ye, Choi Jungwoo, Colley Adam J, de Campos Tatiana A, De Donato Marcos, Santos Isabel K F de Miranda, de Oliveira Carlo J F, Deobald Heather, Devinoy Eve, Donohue Kaitlin E, Dovc Peter, Eberlein Annett, Fitzsimmons Carolyn J, Franzin Alessandra M, Garcia Gustavo R, Genini Sem, Gladney Cody J, Grant Jason R, Greaser Marion L, Green Jonathan A, Hadsell Darryl L, Hakimov Hatam A, Halgren Rob, Harrow Jennifer L, Hart Elizabeth A, Hastings Nicola, Hernandez Marta, Hu Zhi-Liang, Ingham Aaron, Iso-Touru Terhi, Jamis Catherine, Jensen Kirsty, Kapetis Dimos, Kerr Tovah, Khalil Sari S, Khatib Hasan, Kolbehdari Davood, Kumar Charu G, Kumar Dinesh, Leach Richard, Lee Justin C-M, Li Changxi, Logan Krystin M, Malinverni Roberto, Marques Elisa, Martin William F, Martins Natalia F, Maruyama Sandra R, Mazza Raffaele, McLean Kim L, Medrano Juan F, Moreno Barbara T, Moré Daniela D, Muntean Carl T, Nandakumar Hari P, Nogueira Marcelo F G, Olsaker Ingrid, Pant Sameer D, Panzitta Francesca, Pastor Rosemeire C P, Poli Mario A, Poslusny Nathan, Rachagani Satyanarayana, Ranganathan Shoba, Razpet Andrej, Riggs Penny K, Rincon Gonzalo, Rodriguez-Osorio Nelida, Rodriguez-Zas Sandra L, Romero Natasha E, Rosenwald Anne, Sando Lillian, Schmutz Sheila M, Shen Libing, Sherman Laura, Southey Bruce R, Lutzow Ylva Strandberg, Sweedler Jonathan V, Tammen Imke, Telugu Bhanu Prakash V L, Urbanski Jennifer M, Utsunomiya Yuri T, Verschoor Chris P, Waardenberg Ashley J, Wang Zhiquan, Ward Robert, Weikard Rosemarie, Welsh Thomas H, White Stephen N, Wilming Laurens G, Wunderlich Kris R, Yang Jianqi, Zhao Feng-Qi

出版信息

Science. 2009 Apr 24;324(5926):522-8. doi: 10.1126/science.1169588.

DOI:10.1126/science.1169588

PMID:19390049

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2943200/

Abstract

To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.

摘要

为了解反刍动物的生物学特性和进化过程，对牛基因组进行了测序，测序深度约为7倍覆盖度。牛基因组至少包含22,000个基因，有一组14,345个直系同源基因的核心集在七种哺乳动物物种中共享，其中1217个在非真兽类（有袋类或单孔类）基因组中不存在或未被检测到。染色体中牛特异性的进化断点区域具有更高密度的片段重复、重复元件富集以及与泌乳和免疫反应相关基因的物种特异性变异。参与代谢的基因通常高度保守，尽管有五个代谢基因与其人类直系同源基因相比被删除或发生了广泛分歧。因此，牛基因组序列为理解哺乳动物进化以及加速奶牛和肉牛生产的家畜遗传改良提供了资源。