Tavares N R, Moreira P A, Amaral T F
Faculdade de Ciências da Nutrição e Alimentação da Universidade do Porto, Porto, Portugal.
J Nutr Health Aging. 2009 May;13(5):441-6. doi: 10.1007/s12603-009-0081-2.
High levels of total plasma homocysteine are potentially harmful in the elderly.
To investigated the effects of oral riboflavin supplementation on plasma total homocysteine, ferritin, uric acid and C-reactive protein concentration in elderly people with a low riboflavin status. We performed a four-week randomized, placebo-controlled, double-blind trial of riboflavin supplementation in seven Portuguese day social centers.
Eighty-eight individuals (66.7% female), aged between 60 and 94 years, volunteered to participate in the study following interview. Forty-two subjects, with an erythrocyte glutathione reductase activation coefficient (EGRAC) >or= 1.2, were included in the intervention trial. All subjects gave informed consent. Study subjects were administered 10 mg riboflavin (n=21) or placebo (n=21) each day for 28 days.
Riboflavin supplementation significantly decreased plasma tHcy (P=0.005) and EGRAC (P=0.014), but not plasma ferritin, uric acid or C-reactive protein.
In this elderly group, we found that 10 mg/day oral riboflavin supplementation lowered plasma homocysteine concentrations in subjects with low riboflavin status.
血浆总同型半胱氨酸水平升高对老年人可能有害。
研究口服补充核黄素对核黄素水平低的老年人血浆总同型半胱氨酸、铁蛋白、尿酸和C反应蛋白浓度的影响。我们在七个葡萄牙日间社会中心进行了一项为期四周的补充核黄素的随机、安慰剂对照、双盲试验。
88名年龄在60至94岁之间的个体（66.7%为女性）在接受访谈后自愿参加研究。42名红细胞谷胱甘肽还原酶激活系数（EGRAC）≥1.2的受试者被纳入干预试验。所有受试者均签署知情同意书。研究对象每天服用10毫克核黄素（n = 21）或安慰剂（n = 21），持续28天。
补充核黄素显著降低了血浆总同型半胱氨酸（P = 0.005）和EGRAC（P = 0.014），但对血浆铁蛋白、尿酸或C反应蛋白无影响。
在这个老年人群中，我们发现每天口服10毫克核黄素可降低核黄素水平低的受试者的血浆同型半胱氨酸浓度。
