Balan Rajiv, Bavdekar S B, Jadhav Sandhya
Department of Pediatrics, Seth GS Medical College and KEM Hospital, Mumbai, India.
Indian J Pediatr. 2009 May;76(5):469-73. doi: 10.1007/s12098-009-0089-y. Epub 2009 Apr 23.
Local anesthetic agent is not usually used to reduce pain experienced by children undergoing venepuncture. This study was undertaken to determine comparative efficacy of local anesthetic cream, Indian classical instrumental music and placebo, in reducing pain due to venepuncture in children.
Children aged 5-12 yr requiring venepuncture were enrolled in a prospective randomized clinical trial conducted at a tertiary care center. They were randomly assigned to 3 groups: local anesthetic (LA), music or placebo (control) group. Eutactic mixture of local anesthetic agents (EMLA) and Indian classical instrumental music (raaga-Todi) were used in the first 2 groups, respectively. Pain was assessed independently by parent, patient, investigator and an independent observer at the time of insertion of the cannula (0 min) and at 1- and 5 min after the insertion using a Visual Analog Scale (VAS). Kruskal- Wallis and Mann-Whitney U tests were used to assess the difference amongst the VAS scores.
Fifty subjects were enrolled in each group. Significantly higher VAS scores were noted in control (placebo) group by all the categories of observers (parent, patient, investigator, independent observer) at all time points. The VAS scores obtained in LA group were lowest at all time points. However, the difference between VAS scores in LA group were significantly lower than those in music group only at some time-points and with some categories of observers (parent: 1 min; investigator: 0-, 1-, 5 min and independent observer: 5 min).
Pain experienced during venepuncture can be significantly reduced by using EMLA or Indian classical instrumental music. The difference between VAS scores with LA and music is not always significant. Hence, the choice between EMLA and music could be dictated by logistical factors.
局部麻醉剂通常不用于减轻接受静脉穿刺的儿童所经历的疼痛。本研究旨在确定局部麻醉乳膏、印度古典器乐和安慰剂在减轻儿童静脉穿刺疼痛方面的相对疗效。
在一家三级护理中心对年龄在5至12岁需要进行静脉穿刺的儿童进行一项前瞻性随机临床试验。他们被随机分为3组:局部麻醉(LA)组、音乐组或安慰剂(对照)组。前两组分别使用局部麻醉剂的 eutactic 混合物(EMLA)和印度古典器乐(raga-Todi)。在插入套管时(0分钟)以及插入后1分钟和5分钟,由家长、患者、研究者和一名独立观察者使用视觉模拟量表(VAS)独立评估疼痛程度。使用Kruskal-Wallis和Mann-Whitney U检验来评估VAS评分之间的差异。
每组招募了50名受试者。在所有时间点,所有类别的观察者(家长、患者、研究者、独立观察者)在对照(安慰剂)组中记录到的VAS评分显著更高。LA组在所有时间点获得的VAS评分最低。然而,仅在某些时间点和某些类别的观察者中(家长:1分钟;研究者:0、1、5分钟;独立观察者:5分钟),LA组的VAS评分差异显著低于音乐组。
使用EMLA或印度古典器乐可显著减轻静脉穿刺时的疼痛。LA和音乐组VAS评分之间的差异并不总是显著的。因此,EMLA和音乐之间的选择可能由后勤因素决定。