Tak J H, van Bon W H J
Child Care Health Dev. 2006 May;32(3):257-68. doi: 10.1111/j.1365-2214.2006.00578.x.
To compare the effect of eutectic mixture of local anaesthetics (EMLA) and a placebo cream on reported pain and observed distress associated with venepuncture, and to investigate effects of procedural information before and distraction during venepuncture.
Children 3-12 years of age undergoing venepuncture under five experimental and a control condition reported their pain at venepuncture on visual scales. Distress was observed when the child entered the waiting room, just before, and during venepuncture.
Distress increased over the measurement occasions, but a distress-reducing effect of EMLA only was found at the actual venepuncture. The placebo diminished the reported pain, but the effect of EMLA was larger. Procedural information and distraction showed no effects.
EMLA reduces pain from venepuncture. The placebo effect probably results from desirable responding. Behavioural distress is a more direct measure than self-reported pain. More sophisticated designs should be used for the provision of procedural information and distraction.
比较局部麻醉药共熔混合物(EMLA)与安慰剂乳膏对静脉穿刺所致自述疼痛及观察到的痛苦的影响,并研究静脉穿刺前的程序信息及穿刺过程中的分心措施的效果。
3至12岁接受静脉穿刺的儿童在五种实验条件和一种对照条件下,通过视觉量表报告其静脉穿刺时的疼痛。在儿童进入候诊室时、即将进行静脉穿刺时以及穿刺过程中观察其痛苦程度。
在整个测量过程中痛苦程度增加,但仅在实际静脉穿刺时发现EMLA有减轻痛苦的作用。安慰剂减轻了自述疼痛,但EMLA的效果更大。程序信息和分心措施未显示出效果。
EMLA可减轻静脉穿刺引起的疼痛。安慰剂效应可能源于期望反应。行为痛苦比自述疼痛是更直接的测量指标。应采用更复杂的设计来提供程序信息和分心措施。