Kumar Narendra, Singh Surendra, Patro Nisha, Patro Ishan
Jiwaji University, Gwalior, Madhya Pradesh, India.
Inflammopharmacology. 2009 Jun;17(3):181-90. doi: 10.1007/s10787-009-0004-1. Epub 2009 Apr 24.
To assess the protective efficacy of Spirulina platensis against collagen-induced arthritis (CIA) in female Wistar rats based on the changes in paws thickness, serum albumin, cholesterol, lipid peroxidation, alkaline phosphatase and acid phosphatase activities and histology of paw joints.
Arthritis was induced by intradermal injection of Collagen and Freund's adjuvant incomplete suspension at several sites on the back with a dose of 2 mg kg(-1) of body weight and boosted with 0.1 ml intradermally at the base of the tail. CIA rats were orally treated with 200 and 400 mg kg(-1) per oral of S. platensis from 0 to 45th day.
S. platensis at 400 mg kg(-1) per oral significantly elevates serum albumin and decreases the serum cholesterol, alkaline phosphatase and acid phosphatase activities, lipid peroxidation, paw thickness as well as normalize the joint histopathology of CIA rats.
S. platensis (400 mg kg(-1)) significantly normalizes changes observed in arthritic rats to near normal conditions, indicates that S. platensis has promising protective efficacy against CIA rats.
基于爪厚度、血清白蛋白、胆固醇、脂质过氧化、碱性磷酸酶和酸性磷酸酶活性的变化以及爪关节组织学，评估钝顶螺旋藻对雌性Wistar大鼠胶原诱导性关节炎（CIA）的保护作用。
通过在背部多个部位皮内注射胶原蛋白和弗氏不完全佐剂混悬液诱导关节炎，剂量为2mg kg(-1)体重，并在尾根部皮内注射0.1ml进行加强免疫。从第0天至第45天，对CIA大鼠口服给予200和400mg kg(-1)的钝顶螺旋藻。
口服400mg kg(-1)的钝顶螺旋藻可显著提高血清白蛋白水平，降低血清胆固醇、碱性磷酸酶和酸性磷酸酶活性、脂质过氧化、爪厚度，并使CIA大鼠的关节组织病理学恢复正常。
钝顶螺旋藻（400mg kg(-1)）可使关节炎大鼠观察到的变化显著恢复至接近正常状态，表明钝顶螺旋藻对CIA大鼠具有有前景的保护作用。
