Patro Nisha, Sharma Arpita, Kariaya Keerti, Patro Ishan
School of Studies in Neuroscience, Jiwaji University, Gwalior 474 011, India.
Indian J Exp Biol. 2011 Oct;49(10):739-48.
Spirulina platensis treatment (400 mg kg(-1) for 25 days) effectively suppressed peripheral sensitization via modulation of glial activation and improved motor coordination and restoration of functional motor activity in collagen-induced arthritic rats. Spirulina treatment also resulted in an appreciable reduction of the NF200 accumulation in the spinal cord neurons of arthritic rats. This is indicative of neuroprotective action of S. platensis against glutamate excitotoxicity-induced central sensitization produced by the peripheral joint inflammation in the collagen-induced arthritis. The results suggest that effects of S. platensis may be due to its counter regulation of spinal glial activation and could be a potential strategy for the treatment of arthritis.
钝顶螺旋藻治疗（400毫克/千克，持续25天）通过调节胶质细胞活化有效抑制外周敏化，并改善胶原诱导性关节炎大鼠的运动协调性和功能性运动活动的恢复。螺旋藻治疗还导致关节炎大鼠脊髓神经元中NF200积累明显减少。这表明钝顶螺旋藻对胶原诱导性关节炎中由外周关节炎症产生的谷氨酸兴奋性毒性诱导的中枢敏化具有神经保护作用。结果表明，钝顶螺旋藻的作用可能归因于其对脊髓胶质细胞活化的反向调节，并且可能是治疗关节炎的潜在策略。
