Mátrai Zoltán, Németh Júlia, Miklós Katalin, Szabó Zsófia, Masszi Tamás
Department of Haematology and Stem Cell Transplantation, St. László Hospital, Budapest, Hungary.
Clin Chem Lab Med. 2009;47(5):585-9. doi: 10.1515/CCLM.2009.137.
Serum beta2-microglobulin (beta2m) has been established as a marker of disease activity in malignancies, autoimmune conditions and infections. Despite its important role in prognosis assessment and disease monitoring, relatively few studies are available on its expression in healthy individuals. Furthermore, interpretation of results is hampered by the variety in reference limits due to differences in methodology, sample population and statistics.
Serum beta2m concentrations were measured using a microparticle-enhanced immunonephelometric method in 183 healthy blood donors aged 29-75 years.
The median beta2m concentration was 1.67 (0.88-2.75) mg/L with no difference between men and women (1.71 mg/L vs. 1.62 mg/L, p<0.07). A linear correlation was found between beta2m and age (p<0.0001), serum concentrations significantly higher in older subjects (1.55, 1.59, 1.70, and 1.87 mg/L in age groups of 29-40, 40-50, 50-60 and 60-75 years, respectively, p<0.0001). Reference intervals obtained by non-parametric estimation after partitioning by age were 1.02-2.46 mg/L vs. 1.29-2.70 mg/L in younger (29-49 years) vs. older (50-75 years) individuals.
These data can help standardise beta2m reference limits and support age-adjusted comparisons in clinical studies.
血清β2-微球蛋白（β2m）已被确立为恶性肿瘤、自身免疫性疾病和感染中疾病活动的标志物。尽管其在预后评估和疾病监测中具有重要作用，但关于其在健康个体中的表达的研究相对较少。此外，由于方法、样本人群和统计数据的差异，参考限值的多样性阻碍了结果的解释。
采用微粒增强免疫比浊法测定了183名年龄在29 - 75岁的健康献血者的血清β2m浓度。
β2m浓度中位数为1.67（0.88 - 2.75）mg/L，男性和女性之间无差异（1.71 mg/L对1.62 mg/L，p<0.07）。发现β2m与年龄之间存在线性相关性（p<0.0001），老年受试者的血清浓度显著更高（29 - 40岁、40 - 50岁、50 - 60岁和60 - 75岁年龄组的血清浓度分别为1.55、1.59、1.70和1.87 mg/L，p<0.0001）。按年龄划分后通过非参数估计获得的参考区间，年轻（29 - 49岁）个体为1.02 - 2.46 mg/L，老年（50 - 75岁）个体为1.29 - 2.70 mg/L。
这些数据有助于标准化β2m参考限值，并支持临床研究中进行年龄调整后的比较。
