双相障碍患者静息状态下腹侧前额叶皮质和杏仁核低频功能连接。
Functional connectivity between ventral prefrontal cortex and amygdala at low frequency in the resting state in bipolar disorder.
机构信息
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA.
出版信息
Psychiatry Res. 2010 Jun 30;182(3):207-10. doi: 10.1016/j.pscychresns.2010.04.002. Epub 2010 May 20.
Abstract
Trait abnormalities in bipolar disorder (BD) within the ventral prefrontal cortex (vPFC) and the amygdala suggest dysfunction in their connectivity. This study employed low frequency resting state functional magnetic resonance imaging (LFRS-fMRI) to analyze functional connectivity between the vPFC and the amygdala in BD. LFRS-fMRI identified a negative correlation in vPFC-amygdala activity, and the magnitude of this correlation was greater in healthy participants than in subjects with BD. Additionally, whole-brain analysis revealed higher correlations between left and right vPFC in BD, as well as with ventral striatum.
摘要
双相情感障碍（BD）患者腹侧前额叶皮层（vPFC）和杏仁核的特质异常表明其连接功能障碍。本研究采用低频静息态功能磁共振成像（LFRS-fMRI）分析 BD 患者 vPFC 与杏仁核之间的功能连接。LFRS-fMRI 确定了 vPFC-杏仁核活动之间的负相关，并且这种相关性在健康参与者中比在 BD 患者中更大。此外，全脑分析显示 BD 患者左、右 vPFC 与腹侧纹状体之间的相关性更高。
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