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1
Altered corticostriatal functional connectivity in obsessive-compulsive disorder.强迫症患者皮质纹状体功能连接的改变
Arch Gen Psychiatry. 2009 Nov;66(11):1189-200. doi: 10.1001/archgenpsychiatry.2009.152.
2
Resting state corticolimbic connectivity abnormalities in unmedicated bipolar disorder and unipolar depression.未用药的双相情感障碍和单相抑郁症患者静息态皮质-边缘系统连接异常。
Psychiatry Res. 2009 Mar 31;171(3):189-98. doi: 10.1016/j.pscychresns.2008.03.012. Epub 2009 Feb 20.
3
FDG-PET study in pathological gamblers. 1. Lithium increases orbitofrontal, dorsolateral and cingulate metabolism.对病态赌徒的氟代脱氧葡萄糖正电子发射断层扫描（FDG-PET）研究。1. 锂可增加眶额叶、背外侧和扣带回的代谢。
Neuropsychobiology. 2008;58(1):37-47. doi: 10.1159/000154478. Epub 2008 Sep 10.
4
Brain oscillatory responses in patients with bipolar disorder manic episode before and after valproate treatment.双相情感障碍躁狂发作患者在丙戊酸盐治疗前后的脑振荡反应。
Brain Res. 2008 Oct 15;1235:98-108. doi: 10.1016/j.brainres.2008.06.101. Epub 2008 Jul 2.
5
Abnormal corpus callosum integrity in bipolar disorder: a diffusion tensor imaging study.双相情感障碍中胼胝体完整性异常：一项扩散张量成像研究。
Biol Psychiatry. 2008 Oct 15;64(8):730-733. doi: 10.1016/j.biopsych.2008.06.001. Epub 2008 Jul 11.
6
Pilot investigation of the changes in cortical activation during facial affect recognition with lamotrigine monotherapy in bipolar disorder.双相情感障碍患者使用拉莫三嗪单药治疗对面部表情识别过程中皮质激活变化的初步研究。
Br J Psychiatry. 2008 Mar;192(3):197-201. doi: 10.1192/bjp.bp.107.037960.
7
Persistent default-mode network connectivity during light sedation.浅镇静期间默认模式网络连接持续存在。
Hum Brain Mapp. 2008 Jul;29(7):839-47. doi: 10.1002/hbm.20537.
8
Prefrontal function and activation in bipolar disorder and schizophrenia.双相情感障碍和精神分裂症中的前额叶功能与激活
Am J Psychiatry. 2008 Mar;165(3):378-84. doi: 10.1176/appi.ajp.2007.07020365. Epub 2008 Jan 15.
9
Increased volume of the amygdala and hippocampus in bipolar patients treated with lithium.接受锂盐治疗的双相情感障碍患者杏仁核和海马体体积增大。
Neuroreport. 2008 Jan 22;19(2):221-4. doi: 10.1097/WNR.0b013e3282f48108.
10
Evidence for deficient modulation of amygdala response by prefrontal cortex in bipolar mania.双相躁狂症中前额叶皮层对杏仁核反应调节不足的证据。
Psychiatry Res. 2008 Jan 15;162(1):27-37. doi: 10.1016/j.pscychresns.2007.04.007. Epub 2007 Dec 11.

双相障碍患者静息状态下腹侧前额叶皮质和杏仁核低频功能连接。

Functional connectivity between ventral prefrontal cortex and amygdala at low frequency in the resting state in bipolar disorder.

机构信息

Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA.

出版信息

Psychiatry Res. 2010 Jun 30;182(3):207-10. doi: 10.1016/j.pscychresns.2010.04.002. Epub 2010 May 20.

DOI:10.1016/j.pscychresns.2010.04.002
PMID:20493671
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2914819/
Abstract

Trait abnormalities in bipolar disorder (BD) within the ventral prefrontal cortex (vPFC) and the amygdala suggest dysfunction in their connectivity. This study employed low frequency resting state functional magnetic resonance imaging (LFRS-fMRI) to analyze functional connectivity between the vPFC and the amygdala in BD. LFRS-fMRI identified a negative correlation in vPFC-amygdala activity, and the magnitude of this correlation was greater in healthy participants than in subjects with BD. Additionally, whole-brain analysis revealed higher correlations between left and right vPFC in BD, as well as with ventral striatum.

摘要

双相情感障碍（BD）患者腹侧前额叶皮层（vPFC）和杏仁核的特质异常表明其连接功能障碍。本研究采用低频静息态功能磁共振成像（LFRS-fMRI）分析 BD 患者 vPFC 与杏仁核之间的功能连接。LFRS-fMRI 确定了 vPFC-杏仁核活动之间的负相关，并且这种相关性在健康参与者中比在 BD 患者中更大。此外，全脑分析显示 BD 患者左、右 vPFC 与腹侧纹状体之间的相关性更高。