Caruana Paul Chetcuti, Mulaify Sami Al, Moazzez Rebecca, Bartlett David
Department of Prosthodontics, King's College London Dental Institute at Guy's, King's and St Thomas' Dental Hospitals, United Kingdom.
J Dent. 2009 Jul;37(7):522-6. doi: 10.1016/j.jdent.2009.03.010. Epub 2009 Apr 29.
Previous research has shown that regular use of CPP-ACP increases calcium and inorganic phosphates in plaque and reduces enamel mineral loss. The aim of this study was to investigate if a CPP-ACP-containing paste would neutralize acidic challenges in dental plaque following sucrose rinse.
Plaque pH was measured on 15 subjects in a cross-over study with and without prior application of the paste and with and without CPP-ACP. On each occasion, subjects rinsed with 10% sucrose and sorbitol solutions for 2 min in randomized order.
The results showed the median lowest pH without paste was 4.8 (IQR: 4.7-5.0) and with mousse 5.6 (IQR: 5.5-5.6 and p<0.001). The median lowest pH was 5.0 (IQR: 4.9-5.3) without CPP-ACP and with CPP-ACP was 5.8 (5.6-6.1 and p<0.001). The time that pH remained below 5.7 and the time to return to resting pH showed similar differences in all subjects (p<0.01).
The results indicate that prior application of a CPP-ACP-containing paste reduced the fall in plaque pH following a sucrose challenge.
先前的研究表明，经常使用酪蛋白磷酸肽-无定形磷酸钙（CPP-ACP）可增加牙菌斑中的钙和无机磷酸盐，并减少牙釉质矿物质流失。本研究的目的是调查含CPP-ACP的糊剂在蔗糖冲洗后是否能中和牙菌斑中的酸性物质。
在一项交叉研究中，对15名受试者在使用糊剂和未使用糊剂、以及含有和不含有CPP-ACP的情况下测量牙菌斑pH值。每次，受试者随机用10%蔗糖和山梨醇溶液冲洗2分钟。
结果显示，未使用糊剂时最低pH值中位数为4.8（四分位间距：4.7-5.0），使用慕斯时为5.6（四分位间距：5.5-5.6，p<0.001）。不含CPP-ACP时最低pH值中位数为5.0（四分位间距：4.9-5.3），含CPP-ACP时为5.8（5.6-6.1，p<0.001）。在所有受试者中，pH值保持在5.7以下的时间以及恢复到静息pH值的时间显示出类似差异（p<0.01）。
结果表明，预先使用含CPP-ACP的糊剂可减少蔗糖刺激后牙菌斑pH值的下降。
