酪蛋白和含钙糊剂对随后碳水化合物刺激后牙菌斑pH值的影响。

The effect of casein and calcium containing paste on plaque pH following a subsequent carbohydrate challenge.

作者信息

Caruana Paul Chetcuti, Mulaify Sami Al, Moazzez Rebecca, Bartlett David

机构信息

Department of Prosthodontics, King's College London Dental Institute at Guy's, King's and St Thomas' Dental Hospitals, United Kingdom.

出版信息

J Dent. 2009 Jul;37(7):522-6. doi: 10.1016/j.jdent.2009.03.010. Epub 2009 Apr 29.

DOI:10.1016/j.jdent.2009.03.010

PMID:19403229

Abstract

OBJECTIVES

Previous research has shown that regular use of CPP-ACP increases calcium and inorganic phosphates in plaque and reduces enamel mineral loss. The aim of this study was to investigate if a CPP-ACP-containing paste would neutralize acidic challenges in dental plaque following sucrose rinse.

METHOD

Plaque pH was measured on 15 subjects in a cross-over study with and without prior application of the paste and with and without CPP-ACP. On each occasion, subjects rinsed with 10% sucrose and sorbitol solutions for 2 min in randomized order.

RESULTS

The results showed the median lowest pH without paste was 4.8 (IQR: 4.7-5.0) and with mousse 5.6 (IQR: 5.5-5.6 and p<0.001). The median lowest pH was 5.0 (IQR: 4.9-5.3) without CPP-ACP and with CPP-ACP was 5.8 (5.6-6.1 and p<0.001). The time that pH remained below 5.7 and the time to return to resting pH showed similar differences in all subjects (p<0.01).

CONCLUSION

The results indicate that prior application of a CPP-ACP-containing paste reduced the fall in plaque pH following a sucrose challenge.

摘要

目的

先前的研究表明，经常使用酪蛋白磷酸肽-无定形磷酸钙（CPP-ACP）可增加牙菌斑中的钙和无机磷酸盐，并减少牙釉质矿物质流失。本研究的目的是调查含CPP-ACP的糊剂在蔗糖冲洗后是否能中和牙菌斑中的酸性物质。

方法

在一项交叉研究中，对15名受试者在使用糊剂和未使用糊剂、以及含有和不含有CPP-ACP的情况下测量牙菌斑pH值。每次，受试者随机用10%蔗糖和山梨醇溶液冲洗2分钟。

结果

结果显示，未使用糊剂时最低pH值中位数为4.8（四分位间距：4.7-5.0），使用慕斯时为5.6（四分位间距：5.5-5.6，p<0.001）。不含CPP-ACP时最低pH值中位数为5.0（四分位间距：4.9-5.3），含CPP-ACP时为5.8（5.6-6.1，p<0.001）。在所有受试者中，pH值保持在5.7以下的时间以及恢复到静息pH值的时间显示出类似差异（p<0.01）。