School of Dentistry, The University of Adelaide, Adelaide, SA 5005, Australia.
Arch Oral Biol. 2009 Jun;54(6):527-32. doi: 10.1016/j.archoralbio.2009.03.006. Epub 2009 May 2.
In addition to its role as a remineralizing agent in preventing dental caries, recent evidence has shown that casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) can protect teeth against erosion. The aim of this study was to determine whether CPP-ACP could reduce enamel wear rates under severe erosive conditions simulating heavy attrition and gastric regurgitation.
Enamel specimens were subjected to 10,000 wear cycles at a load of 100 N and pH 1.2 in a tooth wear machine. The machine was stopped every 2 min (160 cycles), and CPP-ACP in the form of a paste was applied for 5 min in experimental group 1. A paste with the same formulation but without CPP-ACP was applied in experimental group 2. No paste was applied in the control group.
A linear mixed model analysis indicated that the mean wear rates in experimental group 1 (0.44+/-0.05 mm(3) per 1000 cycles) and in experimental group 2 (0.63+/-0.06 mm(3) per 1000 cycles) were significantly lower than that in the control group (0.92+/-0.11 mm(3) per 1000 cycles) (p<0.05). The mean wear rate in experimental group 1 was also lower than that in experimental group 2 (p<0.05). Wear facets in experimental groups 1 and 2 were noted to be smoother and more polished than those in the control group.
Both remineralizing and lubricating properties of the paste containing CPP-ACP appear to contribute to wear reduction in enamel. These findings may lead to new strategies for the clinical management of tooth wear.
除了作为一种再矿化剂预防龋齿外，最近的证据表明，酪蛋白磷酸肽-无定形磷酸钙（CPP-ACP）可以保护牙齿免受酸蚀。本研究旨在确定 CPP-ACP 是否可以在模拟重度磨损和胃酸反流的严重侵蚀条件下降低牙釉质的磨损率。
将牙釉质标本在牙磨损机上以 100N 的载荷和 pH1.2 的条件下进行 10000 次磨损循环。每 2 分钟（160 次循环）停止机器，实验组 1 中以糊剂形式应用 CPP-ACP 5 分钟。实验组 2 中应用具有相同配方但不含 CPP-ACP 的糊剂。对照组不应用糊剂。
线性混合模型分析表明，实验组 1（每 1000 次循环 0.44+/-0.05mm3）和实验组 2（每 1000 次循环 0.63+/-0.06mm3）的平均磨损率明显低于对照组（每 1000 次循环 0.92+/-0.11mm3）（p<0.05）。实验组 1 的平均磨损率也低于实验组 2（p<0.05）。实验组 1 和 2 的磨损面比对照组更光滑、更抛光。
含 CPP-ACP 的糊剂的再矿化和润滑特性似乎都有助于降低牙釉质的磨损。这些发现可能为牙齿磨损的临床管理提供新的策略。
