Fatemeh Mazhari, Marjan Sharifi, Homa Noorollahian, Mahsa Sharifi
J Clin Pediatr Dent. 2017;41(1):22-26. doi: 10.17796/1053-4628-41.1.22.
There is some evidence that water rinsing immediately after topical fluoride therapy has the potential to reduce the effectiveness of fluoride. The aim was to determine if covering fluoridated teeth with a layer of mousse containing CPP-ACP could prevent the adverse effect of rinsing on fluoride and consequently its buffering effect on dental plaque pH during cariogenic challenge.
This randomized, controlled, crossover, in situ study was conducted on 25 participants. The participants were subjected to acidulated phosphate fluoride (APF) application followed by five treatment protocols: (1) water rinsing after 30 minutes (APF-30) or (2) immediate water rinsing (APF-0); (3) using CPP-ACP immediately before water rinsing (F-CPP-ACP); and two control groups: (4) no fluoride therapy (No-F) and (5) using CPP-ACP and immediate water rinsing (CPP-ACP-0). After 48 hours, teeth were rinsed with 10% sucrose solution and plaque pH was measured before and after 5, 10, 15, 20 and 30 minutes.
The least pH changes, the lowest pH drop, and the quickest pH recovery were found in the APF-30 and F-CPP-ACP groups. APF-0 ranked in the middle and the highest values were in the control groups.
The results show that in the case using CPP-ACP on fluoridated teeth, water rinsing immediately after topical fluoride therapy did not seem to influence the inhibitory effect of fluoride on plaque acidity.
有证据表明，局部用氟治疗后立即用水冲洗可能会降低氟的有效性。本研究旨在确定用一层含酪蛋白磷酸肽-无定形磷酸钙（CPP-ACP）的慕斯覆盖涂氟牙齿是否可以防止冲洗对氟的不良影响，从而防止其在致龋攻击期间对牙菌斑pH值的缓冲作用。
本随机、对照、交叉、原位研究共纳入25名参与者。参与者接受酸化磷酸氟（APF）治疗，随后采用五种治疗方案：（1）30分钟后用水冲洗（APF-30）或（2）立即用水冲洗（APF-0）；（3）在用水冲洗前立即使用CPP-ACP（F-CPP-ACP）；以及两个对照组：（4）不进行氟治疗（无氟组）和（5）使用CPP-ACP并立即用水冲洗（CPP-ACP-0）。48小时后，用10%蔗糖溶液冲洗牙齿，并在5、10、15、20和30分钟前后测量菌斑pH值。
APF-30组和F-CPP-ACP组的pH值变化最小、pH值下降最低且pH值恢复最快。APF-0组居中，对照组的pH值变化最大。
结果表明，在涂氟牙齿上使用CPP-ACP的情况下，局部用氟治疗后立即用水冲洗似乎不会影响氟对菌斑酸度的抑制作用。
