衰老介导的心脏组织氧化还原失衡：绿茶提取物的抗氧化复壮潜力。
Senescence mediated redox imbalance in cardiac tissue: Antioxidant rejuvenating potential of green tea extract.
作者信息
Kumaran Vadivel Senthil, Arulmathi Karpagavinayagam, Kalaiselvi Periandavan
机构信息
Department of Medical Biochemistry, DR.ALM Post-Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India.
出版信息
Nutrition. 2009 Jul-Aug;25(7-8):847-54. doi: 10.1016/j.nut.2009.02.005. Epub 2009 Apr 28.
OBJECTIVE
The activities and capacities of antioxidant systems of tissue cells are declined during aging, leading to the gradual loss of pro-oxidant/antioxidant balance and accumulation of oxidative damage. Hence, the present study evaluated the role of green tea extract (GTE), rich in polyphenols, in combating age-associated macromolecular damage in rat cardiac tissue.
METHODS
The antioxidant defense system, lipid peroxidation, protein oxidation, and redox status in heart tissue were studied using young and aged rats.
RESULTS
Significant increases in lipid peroxidation, protein carbonyls, and marked decreases in glutathione redox status, protein thiols, and activities of enzymatic and non-enzymatic antioxidants were observed in aged rats compared with young rats. Supplementation of GTE (100 mg/kg of body weight per day) orally for 30 days ameliorated these changes significantly.
CONCLUSION
This study accredits GTE's antioxidant rejuvenating potency and its role in the amelioration of senescence-mediated redox imbalance in aged rat cardiac tissue.
目的
在衰老过程中，组织细胞抗氧化系统的活性和能力会下降，导致促氧化剂/抗氧化剂平衡逐渐丧失，氧化损伤积累。因此，本研究评估了富含多酚的绿茶提取物（GTE）在对抗大鼠心脏组织中与年龄相关的大分子损伤方面的作用。
方法
使用年轻和老年大鼠研究心脏组织中的抗氧化防御系统、脂质过氧化、蛋白质氧化和氧化还原状态。
结果
与年轻大鼠相比，老年大鼠的脂质过氧化、蛋白质羰基显著增加，谷胱甘肽氧化还原状态、蛋白质硫醇以及酶促和非酶促抗氧化剂的活性显著降低。口服GTE（每天100mg/kg体重）30天可显著改善这些变化。
结论
本研究证实了GTE的抗氧化恢复活力的效力及其在改善老年大鼠心脏组织中衰老介导的氧化还原失衡方面的作用。
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