Martín M A, Castillo A M, Liébana J, Marín A, Alados J C, Piédrola G
Department of Microbiology, University School of Medicine, University of Granada, Spain.
J Hyg Epidemiol Microbiol Immunol. 1991;35(2):189-97.
We compared the "in vitro" activity of imipenem with 14 beta-lactams, both alone and in combination with clavulanic acid, and sulbactam against 110 beta-lactamase-producing strains of Bacteroides fragilis. The following antibiotics were tested: amoxycillin, penicillin, mezlocillin, piperacillin, cephalothin, cephazolin, cefamandole, cefmetazole, cefonicid, cefoxitin, cefotaxime, ceftazidime, ceftizoxime, and ceftriaxone. In all cases, except those of cefoxitin and cefmetazole, these combinations showed a statistically significant increase in beta-lactam activity, which was, however, never higher than that of imipenem, the antibiotic which performed best against Bacteroides fragilis.
我们比较了亚胺培南与14种β-内酰胺类抗生素单独使用以及与克拉维酸和舒巴坦联合使用时对110株产β-内酰胺酶的脆弱拟杆菌的“体外”活性。测试的抗生素如下：阿莫西林、青霉素、美洛西林、哌拉西林、头孢噻吩、头孢唑林、头孢孟多、头孢美唑、头孢尼西、头孢西丁、头孢噻肟、头孢他啶、头孢唑肟和头孢曲松。在所有情况下，除了头孢西丁和头孢美唑，这些联合用药显示β-内酰胺活性有统计学意义的增加，然而，其活性从未高于亚胺培南，亚胺培南是对脆弱拟杆菌效果最佳的抗生素。
