打破旧范式：自身免疫性关节炎中的Th17细胞
Breaking old paradigms: Th17 cells in autoimmune arthritis.
作者信息
Peck Ariana, Mellins Elizabeth D
机构信息
Department of Pediatrics, Division of Immunology and Transplantation Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
出版信息
Clin Immunol. 2009 Sep;132(3):295-304. doi: 10.1016/j.clim.2009.03.522. Epub 2009 Apr 28.
Abstract
Aberrant helper T cell activation has been implicated in the pathogenesis of an array of autoimmune diseases. In this review, we summarize evidence that suggests the involvement of a novel T cell subset, the Th17 lineage, in rheumatoid arthritis. In particular, we focus on the role of Th17 cells in inducing and perpetuating the chronic inflammation, cartilage damage, and bone erosion that are hallmark phases of joint destruction and consider current and emerging therapies that seek to disrupt the inflammatory Th17 network and shift the immune system back towards homeostasis.
摘要
异常的辅助性T细胞活化与一系列自身免疫性疾病的发病机制有关。在本综述中，我们总结了证据，表明一种新型T细胞亚群，即Th17谱系，参与类风湿性关节炎。特别是，我们关注Th17细胞在诱导和维持慢性炎症、软骨损伤和骨侵蚀中的作用，这些是关节破坏的标志性阶段，并考虑当前和新兴的疗法，旨在破坏炎性Th17网络并使免疫系统恢复到稳态。
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