樱桃在痛风管理中能发挥作用吗？
Is there a role for cherries in the management of gout?
作者信息
Collins Marcum W, Saag Kenneth G, Singh Jasvinder A
机构信息
UAB Hospital, 1720 2nd Avenue South, FOT 839, Birmingham, AL 35294, USA.
University of Alabama at Birmingham, Birmingham, AL, USA.
出版信息
Ther Adv Musculoskelet Dis. 2019 May 17;11:1759720X19847018. doi: 10.1177/1759720X19847018. eCollection 2019.
Despite the availability of effective urate-lowering therapy (ULT) and anti-inflammatory drugs for the treatment of gout, there is considerable interest in novel treatment approaches. Patients with gout often have a multitude of comorbidities, leading to concern over drug-drug interactions and medication adverse events. The cherry is a small nutrient-rich fruit that has garnered a great deal of attention in recent years as a nonpharmacologic option for the treatment of a multitude of disease manifestations. Perhaps a quarter of patients with gout try cherries or cherry products to treat their gout, which have antioxidant and anti-inflammatory (IL-6, TNF-α, IL-1β, IL-8, COX-I and -II) properties, hypouricemic effects, and the ability to downregulate NFkB-mediated osteoclastogenesis. Based on these properties, cherries may reduce both the acute and chronic inflammation associated with recurrent gout flares and its chronic destructive arthropathy. In this review, we explore the potential benefits of cherries and cherry products as a nonpharmacologic option for the treatment of gout.
尽管有有效的降尿酸治疗（ULT）和抗炎药物可用于治疗痛风，但人们对新型治疗方法仍有浓厚兴趣。痛风患者通常有多种合并症，这引发了对药物相互作用和药物不良事件的担忧。樱桃是一种营养丰富的小水果，近年来作为一种非药物选择用于治疗多种疾病表现而备受关注。或许有四分之一的痛风患者会尝试食用樱桃或樱桃制品来治疗痛风，它们具有抗氧化和抗炎（白细胞介素-6、肿瘤坏死因子-α、白细胞介素-1β、白细胞介素-8、环氧化酶-I和-II）特性、降尿酸作用以及下调核因子κB介导的破骨细胞生成的能力。基于这些特性，樱桃可能会减轻与复发性痛风发作及其慢性破坏性关节病相关的急性和慢性炎症。在本综述中，我们探讨樱桃和樱桃制品作为治疗痛风的非药物选择的潜在益处。
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