Zhou Yi-bo, Huang Zhong-xi, Ren Cai-ping, Zhu Bin, Yao Kai-tai
Cancer Research Institute of Central South University, Changsha 410078, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2009 Apr;29(4):645-7.
To screen and analyze the apoptosis- and proliferation-related genes in human nasopharyngeal carcinoma (NPC).
According to gene ontology classification, the abnormal expressions of the genes related to cell apoptosis and proliferation were identified in the NPC gene chip data. The cell apoptosis- and proliferation-related genes expressed in each of the 3 stages, as defined by the tree model for the pathogenesis and progression of NPC, were screened, and with literature review, their distribution in the tree model were analyzed.
Nineteen genes related to cell apoptosis were found in NPC, among which 9 were down-regulated (such as DNASE1L3) and located in the chromosome deletion regions, and 10 were up-regulated (such as DEDD) in the chromosome amplification regions. Twenty-one cell proliferation-related genes were identified, including 8 down-regulated genes (such as TUSC2) in the chromosome deletion regions and 13 up-regulated ones (such as EMP1) in the chromosome amplification regions. In the chromosome deletion regions, the down-regulated cell apoptosis-related genes participated mostly in inducing and regulating cell apoptosis, and the up-regulated cell proliferation-related genes in the chromosome amplification regions were mostly associated with the positive regulation of cell proliferation.
NPC occurs possibly through two pathways by inhibiting cell apoptosis or by promoting excessive cell proliferation.
筛选并分析人鼻咽癌（NPC）中与细胞凋亡和增殖相关的基因。
根据基因本体分类，在NPC基因芯片数据中鉴定与细胞凋亡和增殖相关的基因的异常表达。筛选在NPC发病机制和进展的树状模型所定义的3个阶段中每个阶段表达的细胞凋亡和增殖相关基因，并通过文献综述分析它们在树状模型中的分布。
在NPC中发现19个与细胞凋亡相关的基因，其中9个下调（如DNASE1L3）且位于染色体缺失区域，10个上调（如DEDD）于染色体扩增区域。鉴定出21个与细胞增殖相关的基因，包括8个下调基因（如TUSC2）位于染色体缺失区域和13个上调基因（如EMP1）于染色体扩增区域。在染色体缺失区域，下调的细胞凋亡相关基因主要参与诱导和调节细胞凋亡，而在染色体扩增区域上调的细胞增殖相关基因大多与细胞增殖的正调控相关。
NPC可能通过抑制细胞凋亡或促进细胞过度增殖这两条途径发生。
