Knouf Emily C, Metzger Michael J, Mitchell Patrick S, Arroyo Jason D, Chevillet John R, Tewari Muneesh, Miller A Dusty
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA.
J Virol. 2009 Jul;83(14):7353-6. doi: 10.1128/JVI.00546-09. Epub 2009 Apr 29.
The human retrovirus XMRV (xenotropic murine leukemia virus-related virus) is associated with prostate cancer, most frequently in humans with a defect in the antiviral defense protein RNase L, suggesting a role for XMRV in prostate carcinogenesis. However, XMRV has not been found in prostate carcinoma cells. Here we show that 22Rv1 prostate carcinoma cells produce high-titer virus that is nearly identical in properties and sequence to XMRV isolated by others and consist primarily of a single clone of cells with at least 10 integrated copies of XMRV, warranting further study of a possible role for XMRV integration in carcinogenesis.
人类逆转录病毒XMRV（异嗜性小鼠白血病病毒相关病毒）与前列腺癌有关，在抗病毒防御蛋白核糖核酸酶L有缺陷的人类中最为常见，这表明XMRV在前列腺癌发生过程中发挥了作用。然而，在前列腺癌细胞中尚未发现XMRV。在此我们表明，22Rv1前列腺癌细胞产生高滴度病毒，其特性和序列与其他人分离出的XMRV几乎相同，并且主要由具有至少10个XMRV整合拷贝的单一细胞克隆组成，这使得有必要进一步研究XMRV整合在致癌过程中的可能作用。
