Fukui Toshiya, Lee Eiyai
Division of Neurology, Department of Internal Medicine, Showa University Northern Yokohama Hospital, Tsuzuki-ku, Yokohama, Kanagawa-prefecture, 224-8503, Japan.
Am J Alzheimers Dis Other Demen. 2009 Aug-Sep;24(4):313-21. doi: 10.1177/1533317509333903. Epub 2009 Apr 29.
Contribution of visuospatial abilities to the functional status in patients with Alzheimer's disease (AD) has been controversial.
To address whether visuospatial abilities have independent association with functional measures in patients with AD.
We regressed performances on a global cognitive (the revised Hasegawa Dementia Scale: HDSR), executive/ visuoconstruction (Clock drawing), visuoperception (Clock reading: CRT), simple visuoconstruction (figure copying), and frontal behavioral tasks on measures of basic and instrumental activities of daily living (BADL and IADL) in 57 patients (78.0 + 6.1 years) with AD of various severity (mean HDSR score: 16.0 + 5.9). We sought independent contributions of these visuospatial measures to functional status.
Performance on the CRT contributed significantly to BADL and IADL and the results of HDSR contributed to IADL. Results of figure copying related significantly to BADL especially in mild AD.
Visuospatial ability is one of the important contributors to functional status.
视觉空间能力对阿尔茨海默病（AD）患者功能状态的影响一直存在争议。
探讨视觉空间能力与AD患者功能指标是否存在独立关联。
我们对57例（78.0±6.1岁）不同严重程度（平均修订长谷川痴呆量表[HDSR]评分：16.0±5.9）的AD患者进行了研究，将其在整体认知（修订的长谷川痴呆量表：HDSR）、执行/视觉构建（画钟）、视觉感知（读钟：CRT）、简单视觉构建（图形临摹）以及额叶行为任务方面的表现，与基本日常生活活动（BADL）和工具性日常生活活动（IADL）的测量指标进行回归分析。我们探寻这些视觉空间测量指标对功能状态的独立影响。
CRT表现对BADL和IADL有显著影响，HDSR结果对IADL有影响。图形临摹结果与BADL显著相关，尤其在轻度AD患者中。
视觉空间能力是功能状态的重要影响因素之一。
