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在小鼠卵子着床时中性多形核白细胞浸润至子宫内膜基质以及油诱导蜕膜细胞反应的起始。

Infiltration of neutrophil polymorphonuclear leucocytes into the endometrial stroma at the time of implantation of ova and the initiation of the oil decidual cell reaction in mice.

作者信息

Finn C A, Pope M D

机构信息

Department of Veterinary Preclinical Sciences, University of Liverpool Veterinary Field Station, South Wirral, Cheshire, UK.

出版信息

J Reprod Fertil. 1991 Jan;91(1):365-9. doi: 10.1530/jrf.0.0910365.

DOI:10.1530/jrf.0.0910365
PMID:1995859
Abstract

Polymorphonuclear leucocytes (polymorphs) were found in the endometrial stroma adjacent to implanting blastocysts approximately 100 h after mating. Areas of uterus not containing a blastocyst had very few polymorphs. Ovariectomized mice were treated with hormones to render them sensitive to a decidual stimulus, the intraluminal injection of arachis oil. Areas of uterus responding to the oil (as indicated by the Pontamine Sky Blue reaction) showed an influx of leucocytes into the endometrial stroma between 16 and 36 h after the application of the decidual stimulus. The polymorphs were largely neutrophils. The injection of oil into non-sensitized uteri did not result in polymorph infiltration nor did the injection of physiological saline (which is not deciduogenic) into sensitized uteri. It is concluded that during the early stages of decidualization there is attraction of polymorphs from the blood into the stroma.

摘要

交配后约100小时,在与着床胚泡相邻的子宫内膜基质中发现了多形核白细胞(多形核细胞)。未含胚泡的子宫区域多形核细胞极少。对去卵巢小鼠进行激素处理,使其对蜕膜刺激(即腔内注射花生油)敏感。子宫对油产生反应的区域(以滂胺天蓝反应表示)在施加蜕膜刺激后16至36小时之间,可见白细胞流入子宫内膜基质。多形核细胞主要是中性粒细胞。向未致敏的子宫注射油不会导致多形核细胞浸润,向致敏的子宫注射生理盐水(不具有致蜕膜作用)也不会导致这种情况。得出的结论是,在蜕膜化早期,多形核细胞从血液被吸引到基质中。

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