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Kinetic proofreading of gene activation by chromatin remodeling.

作者信息

Blossey R, Schiessel H

出版信息

HFSP J. 2008 Jun;2(3):167-70. doi: 10.2976/1.2909080. Epub 2008 Apr 22.

Abstract

Gene activation in eukaryotes involves the concerted action of histone tail modifiers, chromatin remodelers, and transcription factors, whose precise coordination is currently unknown. We demonstrate that the experimentally observed interactions of the molecules are in accord with a kinetic proofreading scheme. Our finding could provide a basis for the development of quantitative models for gene regulation in eukaryotes based on the combinatorical interactions of chromatin modifiers.

摘要

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