从DNA纳米技术到合成生物学。
From DNA nanotechnology to synthetic biology.
作者信息
Jungmann Ralf, Renner Stephan, Simmel Friedrich C
机构信息
Physics Department E14, Technical University Munich, James-Franck-Strasse, 85748 Garching, Germany.
出版信息
HFSP J. 2008 Apr;2(2):99-109. doi: 10.2976/1.2896331. Epub 2008 Mar 19.
Abstract
Attempts to construct artificial systems from biological molecules such as DNA and RNA by self-assembly are compatible with the recent development of synthetic biology. Genetic mechanisms can be used to produce or control artificial structures made from DNA and RNA, and these structures can in turn be used as artificial gene regulatory elements, in vitro as well as in vivo. Artificial biochemical circuits can be incorporated into cell-like reaction compartments, which opens up the possibility to operate them permanently out of equilibrium. In small systems, stochastic effects become noticeable and will have to be accounted for in the design of future systems.
摘要
通过自组装利用诸如DNA和RNA等生物分子构建人工系统的尝试与合成生物学的最新发展相契合。遗传机制可用于产生或控制由DNA和RNA制成的人工结构，这些结构反过来又可作为人工基因调控元件，在体外以及体内发挥作用。人工生化电路可被整合到类似细胞的反应隔室中，这为在非平衡状态下永久操作它们开辟了可能性。在小系统中，随机效应变得显著，并且在未来系统的设计中必须予以考虑。
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