Wong Kenneth K Y, Cheung Stephanie O F, Huang Liuming, Niu Jun, Tao Chang, Ho Chi-Ming, Che Chi-Ming, Tam Paul K H
Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong SAR, China.
ChemMedChem. 2009 Jul;4(7):1129-35. doi: 10.1002/cmdc.200900049.
The production of pure silver in nanoparticle size has opened new dimensions in the clinical use of this precious metal. We and others have demonstrated previously that silver nanoparticles (nAg) possess efficient antimicrobial activity. Herein we show they may also have significant anti-inflammatory effects in a postoperative peritoneal adhesion model. This finding provides further insight into the biological actions of nAg as well as a potentially novel therapy for peritoneal adhesions in clinical surgery.With the advent of nanoscience, pure silver can now be made into nanometer-sized particles. As a result, we are able to explore the potentially beneficial properties of pure silver. In our previous study using a burn wound model in mice, we demonstrated that besides antibacterial action, silver nanoparticles (nAg) appear to have anti-inflammatory properties. Herein we further confirm the anti-inflammatory effects of nAg and explore their potential clinical application through a postoperative peritoneal adhesion model. We also elucidate the potential mechanism of action of silver. Our in vitro and in vivo experimental findings show that nAg are effective at decreasing inflammation in peritoneal adhesions without significant toxic effects. This study thus provides further evidence for and contributes to the understanding of the anti-inflammatory properties of nAg and may also give a novel therapeutic direction for the prevention of postoperative adhesions.
纳米级纯银的生产为这种贵金属的临床应用开辟了新的维度。我们和其他人之前已经证明，银纳米颗粒（nAg）具有高效的抗菌活性。在此我们表明，它们在术后腹膜粘连模型中可能也具有显著的抗炎作用。这一发现进一步揭示了nAg的生物学作用，以及为临床手术中腹膜粘连提供了一种潜在的新疗法。随着纳米科学的出现，现在可以将纯银制成纳米级颗粒。因此，我们能够探索纯银的潜在有益特性。在我们之前使用小鼠烧伤创面模型的研究中，我们证明除了抗菌作用外，银纳米颗粒（nAg）似乎还具有抗炎特性。在此我们进一步证实了nAg的抗炎作用，并通过术后腹膜粘连模型探索其潜在的临床应用。我们还阐明了银的潜在作用机制。我们的体外和体内实验结果表明，nAg在减轻腹膜粘连炎症方面有效，且无明显毒性作用。因此，本研究为理解nAg的抗炎特性提供了进一步的证据，并可能为预防术后粘连提供新的治疗方向。
