Tian Jun, Wong Kenneth K Y, Ho Chi-Ming, Lok Chun-Nam, Yu Wing-Yiu, Che Chi-Ming, Chiu Jen-Fu, Tam Paul K H
Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China.
ChemMedChem. 2007 Jan;2(1):129-36. doi: 10.1002/cmdc.200600171.
Wound healing is a complex process and has been the subject of intense research for a long time. The recent emergence of nanotechnology has provided a new therapeutic modality in silver nanoparticles for use in burn wounds. Nonetheless, the beneficial effects of silver nanoparticles on wound healing remain unknown. We investigated the wound-healing properties of silver nanoparticles in an animal model and found that rapid healing and improved cosmetic appearance occur in a dose-dependent manner. Furthermore, through quantitative PCR, immunohistochemistry, and proteomic studies, we showed that silver nanoparticles exert positive effects through their antimicrobial properties, reduction in wound inflammation, and modulation of fibrogenic cytokines. These results have given insight into the actions of silver and have provided a novel therapeutic direction for wound treatment in clinical practice.
伤口愈合是一个复杂的过程，长期以来一直是深入研究的主题。纳米技术的最新出现为用于烧伤创面的银纳米颗粒提供了一种新的治疗方式。尽管如此，银纳米颗粒对伤口愈合的有益作用仍不清楚。我们在动物模型中研究了银纳米颗粒的伤口愈合特性，发现其能以剂量依赖的方式促进伤口快速愈合并改善外观。此外，通过定量聚合酶链反应、免疫组织化学和蛋白质组学研究，我们表明银纳米颗粒通过其抗菌特性、减轻伤口炎症以及调节促纤维化细胞因子发挥积极作用。这些结果深入了解了银的作用，并为临床实践中的伤口治疗提供了新的治疗方向。
