Moni Lisa, Pourceau Gwladys, Zhang Jing, Meyer Albert, Vidal Sébastien, Souteyrand Eliane, Dondoni Alessandro, Morvan François, Chevolot Yann, Vasseur Jean-Jacques, Marra Alberto
Dipartimento di Chimica, Laboratorio di Chimica Organica, Università di Ferrara, Via L. Borsari 46, 44100, Ferrara, Italy.
Chembiochem. 2009 May 25;10(8):1369-78. doi: 10.1002/cbic.200900024.
Sugar-coated chips: Glycoside clusters are valuable tools for carbohydrate-lectin recognition studies. However, the spatial arrangement of the sugar residues is a key issue in the design of high-affinity glycoclusters. Here the affinities of linear and antenna- and calixarene-based galactoside clusters towards two lectins derived from Pseudomonas aeruginosa and Ricinus communis were compared by means of glycoarrays.Interactions between proteins and carbohydrates are involved in a large number of crucial biological events. Many efforts have been devoted to the design and synthesis of unnatural saccharides displaying high affinities towards targeted lectins. Among others, glycoside clusters have proven to be valuable tools for these recognition studies. However, the spatial arrangements of the sugar residues are a key issue in the design of high-affinity glycoclusters. Here, the affinities of linear and antenna- and calixarene-based galactoside clusters against two lectins, derived from Pseudomonas aeruginosa and Ricinus communis, have been compared by means of glycoarrays.
糖苷簇是碳水化合物-凝集素识别研究的重要工具。然而，糖残基的空间排列是设计高亲和力糖簇的关键问题。在此，通过糖阵列比较了基于线性、天线状和杯芳烃的半乳糖苷簇对源自铜绿假单胞菌和蓖麻的两种凝集素的亲和力。蛋白质与碳水化合物之间的相互作用涉及大量关键的生物事件。许多研究致力于设计和合成对靶向凝集素具有高亲和力的非天然糖类。其中，糖苷簇已被证明是这些识别研究的重要工具。然而，糖残基的空间排列是设计高亲和力糖簇的关键问题。在此，通过糖阵列比较了基于线性、天线状和杯芳烃的半乳糖苷簇对源自铜绿假单胞菌和蓖麻的两种凝集素的亲和力。
