Yokozawa Takako, Park Chan Hum, Noh Jeong Sook, Tanaka Takashi, Cho Eun Ju
Institute of Natural Medicine, University of Toyama, Sugitani, Toyama, Japan.
J Pharm Pharmacol. 2009 May;61(5):653-61. doi: 10.1211/jpp/61.05.0015.
We investigated the lipid-lowering activity of 7-O-galloyl-D-sedoheptulose, an active component of Corni Fructus, and related mechanisms.
Rats were fed a high-fructose diet for 6 days, followed by treatment with 7-O-galloyl-D-sedoheptulose, 5, 10 or 20 mg/kg per day, or fenofibrate (positive control).
The high-fructose diet induced an increase in body weight, hypertriglyceridaemia, hyperglycaemia and hypertension. Administration of 7-O-galloyl-D-sedoheptulose significantly reduced the levels of triglyceride in the serum and liver (being more effective than fenofibrate) but did not lead to changes in liver weight or hepatic function, whereas fenofibrate increased the liver weight markedly. The preventive effect of 7-O-galloyl-D-sedoheptulose against the accumulation of triglyceride and cholesterol was related to the up-regulation of peroxisome proliferator-activated receptor alpha expression.
The present study supports the role of 7-O-galloyl-D-sedoheptulose as a promising agent against hypertriglyceridaemia without hepatic side-effects.
我们研究了山茱萸活性成分7 - O - 没食子酰基 - D - 景天庚酮糖的降脂活性及其相关机制。
大鼠先喂食高果糖饮食6天，然后分别用7 - O - 没食子酰基 - D - 景天庚酮糖（每天5、10或20毫克/千克）或非诺贝特（阳性对照）进行处理。
高果糖饮食导致体重增加、高甘油三酯血症、高血糖症和高血压。给予7 - O - 没食子酰基 - D - 景天庚酮糖可显著降低血清和肝脏中的甘油三酯水平（比非诺贝特更有效），但不会导致肝脏重量或肝功能发生变化，而非诺贝特则显著增加肝脏重量。7 - O - 没食子酰基 - D - 景天庚酮糖对甘油三酯和胆固醇积累的预防作用与过氧化物酶体增殖物激活受体α表达的上调有关。
本研究支持7 - O - 没食子酰基 - D - 景天庚酮糖作为一种有前景的抗高甘油三酯血症药物且无肝脏副作用的作用。
