Zhang Bin, Xing Yuehan, Li Zhenwei, Zhou Hongyu, Mu Qingxin, Yan Bing
School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
Nano Lett. 2009 Jun;9(6):2280-4. doi: 10.1021/nl900437n.
Although carbon nanotubes (CNTs) have been shown to nonspecifically bind proteins through charge complementary, pi-pi stacking or hydrophobic interactions, they have not been shown to bind to a specific site on proteins. By generating surface molecular diversity, we created functionalized CNTs that recognize and bind to the catalytic site of alpha-chymotrypsin and inhibit its enzymatic activity competitively.
尽管碳纳米管(CNTs)已被证明可通过电荷互补、π-π堆积或疏水相互作用非特异性结合蛋白质,但尚未证明它们能与蛋白质上的特定位点结合。通过产生表面分子多样性,我们制备了能识别并结合α-胰凝乳蛋白酶催化位点并竞争性抑制其酶活性的功能化碳纳米管。