Vafa Manijeh, Maiga Bakary, Israelsson Elisabeth, Dolo Amagana, Doumbo Ogobara K, Troye-Blomberg Marita
Department of Immunology, Stockholm University, S-106 91 Stockholm, Sweden.
Microbes Infect. 2009 Jul-Aug;11(8-9):779-84. doi: 10.1016/j.micinf.2009.04.017. Epub 2009 May 4.
This study aimed to examine the effect of IL-4 -590 T/C polymorphism on the levels of malaria-specific IgE, IgG, IgG (1-4) subclasses as well as total IgE in the Fulani and their sympatric ethnic group, the Dogon, in Mali. Asymptomatic individuals, of the Fulani and the Dogon ethnic groups, were included in the study. IL-4 is involved in the regulation of IgE and IgG4 subclass. In line with this we found that within the Fulani, the T allele was associated with increased levels of total and anti-malarial IgE (P=0.02 and P=0.04, respectively). The Fulani T allele carriers had slightly higher levels of malarial specific IgG4 as compared to those with the CC genotype (P=0.08). No such differences were observed amongst the Dogon individuals. Taken together, these data indicate that the impact of IL-4 -590 variants on antibody levels may vary in different ethnic populations, and that this might affect the Ig-class and subclass distributions.
本研究旨在探讨白细胞介素-4（IL-4）-590 T/C多态性对马里富拉尼族及其同域民族多贡族疟疾特异性IgE、IgG、IgG（1-4）亚类以及总IgE水平的影响。本研究纳入了富拉尼族和多贡族的无症状个体。IL-4参与IgE和IgG4亚类的调节。与此一致的是，我们发现在富拉尼族中，T等位基因与总IgE和抗疟疾IgE水平升高相关（分别为P = 0.02和P = 0.04）。与CC基因型个体相比，富拉尼族T等位基因携带者的疟疾特异性IgG4水平略高（P = 0.08）。在多贡族个体中未观察到此类差异。综上所述，这些数据表明IL-4 -590变异对抗体水平的影响在不同种族人群中可能有所不同，这可能会影响Ig类和亚类的分布。
