Lopez-Espinosa M J, Freire C, Arrebola J P, Navea N, Taoufiki J, Fernandez M F, Ballesteros O, Prada R, Olea N
Laboratory of Medical Investigations, San Cecilio University Hospital, University of Granada, CIBER de Epidemiología y Salud Pública (CIBERESP), 18071 Granada, Spain.
Chemosphere. 2009 Aug;76(6):847-52. doi: 10.1016/j.chemosphere.2009.03.063. Epub 2009 May 5.
Alkylphenols (APs) and AP ethoxylates are environmental contaminants with endocrine disrupting activities in wildlife and humans. They have been largely used in industrial, agricultural, and domestic applications. Despite strong concerns about the consequences of human exposure to endocrine disrupters, little information is available on the presence in humans of compounds such as APs. The aim of the present study was to determine 4-nonylphenol (NP) and 4-octylphenol (OP) residues in adipose tissue of non-occupationally exposed women living in Southern Spain. NP was detected in 100% (n=20/20) and OP in 23.5% (n=4/20) of samples, with median levels of 57 and 4.5 ng g(-1) adipose tissue, respectively. Body mass index emerged as a determinant of exposure since it was associated with NP levels (p=0.041). Adipose tissue NP and OP levels are similar to the few data previously published in other countries. This is the first report on NP and OP levels in a population in Southern Spain. Further research is needed to determine trends in human exposure to these compounds and to investigate their consequences.
烷基酚（APs）和AP乙氧基化物是具有内分泌干扰活性的环境污染物，对野生动物和人类均有影响。它们已广泛应用于工业、农业和家庭领域。尽管人们对人类接触内分泌干扰物的后果深感担忧，但关于人体中APs等化合物的存在情况，目前所知甚少。本研究旨在测定居住在西班牙南部的非职业暴露女性脂肪组织中的4-壬基酚（NP）和4-辛基酚（OP）残留量。在100%（n = 20/20）的样本中检测到NP，在23.5%（n = 4/20）的样本中检测到OP，脂肪组织中NP和OP的中位数水平分别为57和4.5 ng g(-1)。体重指数成为暴露的一个决定因素，因为它与NP水平相关（p = 0.041）。脂肪组织中NP和OP的水平与其他国家此前发表的少数数据相似。这是关于西班牙南部人群中NP和OP水平的首份报告。需要进一步研究以确定人类接触这些化合物的趋势，并调查其后果。
