Department of Neurology, Boston University School of Medicine, Boston, MA, and VA Boston Healthcare System, Boston, MA, USA.
Neuropsychiatr Dis Treat. 2006 Sep;2(3):341-8. doi: 10.2147/nedt.2006.2.3.341.
To study clinical correlates of religiosity in Parkinson's disease (PD).
Measures of life goals, religiosity, mood, and neuropsychologic function were assessed in 22 persons with mid-stage PD and 20 age-matched healthy controls. Levodopa dose equivalents (LDE) were also computed for the patients.
Relative to other major life goals parkinsonian patients were significantly more likely to report that "my religion or life philosophy" was less important than were age-matched controls. Scores on a battery of religiosity scales were consistently lower for Parkinson's patients than those of age-matched controls. While Mini Mental State Exam, logical memory recall, Stroop, and selected (depression and anxiety) mood scales reliably distinguished patients from controls, only measures of prefrontal function correlated with religiosity scores.
Patients with PD express less interest in religion and report consistently lower scores on measures of religiosity than age-matched controls. Prefrontal dopaminergic networks may support motivational aspects of religiosity.
研究帕金森病（PD）患者宗教信仰的临床相关性。
对 22 名处于疾病中期的 PD 患者和 20 名年龄匹配的健康对照者进行了生活目标、宗教信仰、情绪和神经心理功能的评估。还为患者计算了左旋多巴等效剂量（LDE）。
与其他主要生活目标相比，帕金森病患者报告“我的宗教或生活哲学”不如年龄匹配的对照组重要的可能性明显更高。帕金森病患者的宗教信仰量表得分始终低于年龄匹配的对照组。虽然简易精神状态检查、逻辑记忆回忆、Stroop 以及选定的（抑郁和焦虑）情绪量表可靠地区分了患者和对照组，但只有前额叶功能的测量与宗教信仰评分相关。
PD 患者对宗教的兴趣较低，对宗教信仰的测量得分也明显低于年龄匹配的对照组。前额叶多巴胺能网络可能支持宗教信仰的动机方面。
