Comings D E, Gonzales N, Saucier G, Johnson J P, MacMurray J P
Department of Medical Genetics, City of Hope Medical Center, Duarte, California, USA.
Psychiatr Genet. 2000 Dec;10(4):185-9. doi: 10.1097/00041444-200010040-00006.
Two hundred male subjects (81 college students and 119 subjects from an addiction treatment unit) were administered the Temperament and Character Inventory (TCI) and genotyped at the 48 base pair repeat polymorphism of the DRD4 gene. Subjects were divided by genotype into those carrying any < 4 repeat allele, those homozygous for the 4 repeat allele, and those with any > 4 repeat allele. The total MANCOVA of seven TCI summary scores, with age and diagnostic group as covariates, was significant (P < or = 0.001). The largest effect was with self-transcendence (P < or = 0.001). The total MANCOVA for the three self-transcendence subscores was significant (P < or = 0.017), with the spiritual acceptance subscore showing the most effect (P < or = 0.001, power = 0.91). These results suggest the DRD4 gene may play a role in the personality trait of spiritual acceptance. This may be a function of the high concentration of the dopamine D4 receptor in the cortical areas, especially the frontal cortex.
对200名男性受试者（81名大学生和119名来自成瘾治疗机构的受试者）进行了气质与性格量表（TCI）测试，并对其DRD4基因的48个碱基对重复多态性进行基因分型。受试者根据基因型分为携带任何<4重复等位基因者、4重复等位基因纯合子以及携带任何>4重复等位基因者。以年龄和诊断组作为协变量，对七个TCI总分进行的总体多变量协方差分析具有显著性（P≤0.001）。最大的影响在于自我超越（P≤0.001）。对三个自我超越子分数进行的总体多变量协方差分析具有显著性（P≤0.017），其中精神接纳子分数的影响最为显著（P≤0.001，检验效能=0.91）。这些结果表明，DRD4基因可能在精神接纳这一个性特质中发挥作用。这可能是由于多巴胺D4受体在皮质区域尤其是额叶皮质中高度集中所致。
