Fujimoto Jiro, Sato Eriko
Department of Obstetrics and Gynecology, Graduate School of Medicine, Gifu University School of Medicine, 1-1 Yanagido, Gifu City 501-1194, Japan.
J Steroid Biochem Mol Biol. 2009 Aug;116(1-2):71-5. doi: 10.1016/j.jsbmb.2009.04.012. Epub 2009 May 3.
Estrogen receptor (ER)alpha and ERbeta mRNAs levels decreased with clinical stage, myometrial invasion and dedifferentiation. On the other hand, ERRalpha mRNA levels and histoscores increased with clinical stage and myometrial invasion, regardless of dedifferentiation. ERRalpha can bind to the steroid receptor coactivator family without any ligands, and drive transcription activity of the target genes. The competitive interaction of ERRalpha/ER expression associated with the use of common cofactors during loosing estrogen dependency might cause their expression manner. The up-regulation of ERRalpha might be related to tumor growth and advancement in uterine endometrial cancers. It is speculated that ERRalpha is a candidate for prognostic factors in uterine endometrial cancer, although ERRs are not directly related to growth of uterine endometrial cancer.
雌激素受体（ER）α和ERβ的mRNA水平随临床分期、肌层浸润和去分化而降低。另一方面，ERRα的mRNA水平和组织学评分随临床分期和肌层浸润而增加，与去分化无关。ERRα可以在没有任何配体的情况下与类固醇受体共激活因子家族结合，并驱动靶基因的转录活性。在失去雌激素依赖性的过程中，ERRα/ER表达的竞争性相互作用与共同辅助因子的使用相关，这可能导致它们的表达方式。ERRα的上调可能与子宫内膜癌的肿瘤生长和进展有关。据推测，ERRα是子宫内膜癌预后因素的候选者，尽管ERRs与子宫内膜癌的生长没有直接关系。
