Schüler-Toprak Susanne, Skrzypczak Maciej, Gründker Carsten, Ortmann Olaf, Treeck Oliver
Department of Obstetrics and Gynecology, University Medical Center Regensburg, Caritas-Hospital St. Josef, 93053 Regensburg, Germany.
Second Department of Gynecology, Medical University of Lublin, 20-954 Lublin, Poland.
Cancers (Basel). 2023 May 20;15(10):2845. doi: 10.3390/cancers15102845.
Ovarian and endometrial cancers are affected by estrogens and their receptors. It has been long known that in different types of cancers, estrogens activate tumor cell proliferation via estrogen receptor α (ERα). In contrast, the role of ERs discovered later, including ERβ and G-protein-coupled ER (GPER1), in cancer is less well understood, but the current state of knowledge indicates them to have a considerable impact on both cancer development and progression. Moreover, estrogen related receptors (ERRs) have been reported to affect pathobiology of many tumor types. This article provides a summary and update of the current findings on the role of ERβ, GPER1, and ERRs in ovarian and endometrial cancer. For this purpose, original research articles on the role of ERβ, GPER1, and ERRs in ovarian and endometrial cancers listed in the PubMed database have been reviewed.
卵巢癌和子宫内膜癌受雌激素及其受体的影响。长期以来人们都知道，在不同类型的癌症中，雌激素通过雌激素受体α（ERα）激活肿瘤细胞增殖。相比之下，后来发现的雌激素受体，包括ERβ和G蛋白偶联雌激素受体（GPER1），在癌症中的作用了解较少，但目前的知识状况表明它们对癌症的发生和发展都有相当大的影响。此外，据报道，雌激素相关受体（ERRs）会影响许多肿瘤类型的病理生物学。本文总结并更新了目前关于ERβ、GPER1和ERRs在卵巢癌和子宫内膜癌中作用的研究结果。为此，对PubMed数据库中列出的关于ERβ、GPER1和ERRs在卵巢癌和子宫内膜癌中作用的原始研究文章进行了综述。
