Fujimoto Jiro, Alam Syed Mahfuzul, Jahan Israt, Sato Eriko, Sakaguchi Hideki, Tamaya Teruhiko
Department of Obstetrics and Gynecology, Gifu University School of Medicine, 1-1 Yanagido, Gifu City 501-1194, Japan.
J Steroid Biochem Mol Biol. 2007 May;104(3-5):301-4. doi: 10.1016/j.jsbmb.2007.03.016. Epub 2007 Mar 23.
The expression of estrogen receptor (ER)alpha and ERbeta mRNAs did not show any specific manner according to clinical backgrounds in ovarian cancers. On the other hand, the levels of estrogen-related receptor (ERR)alpha mRNA increased with clinical stages regardless of histopathological types in ovarian cancers. However, ERRbeta and ERRgamma mRNA levels were extremely low to determine reliably. ERRalpha can bind to the steroid receptor coactivator family without any ligands, and drive transcription activity of the target genes. The manner of ERR and ER gene expressions might show an independent usage of common cofactors. It is speculated that the up regulation of ERRalpha might be related to advancement of ovarian cancers regardless of plausible interaction via cofactors regulated by ERs. Although ERRalpha is not directly related to growth of ovarian cancer, ERRalpha is a candidate for prognostic factors for ovarian cancer.
在卵巢癌中，雌激素受体（ER）α和ERβ mRNA的表达根据临床背景未显示出任何特定模式。另一方面，雌激素相关受体（ERR）α mRNA的水平随着卵巢癌临床分期的增加而升高，与组织病理学类型无关。然而，ERRβ和ERRγ mRNA水平极低，难以可靠测定。ERRα可在无任何配体的情况下与类固醇受体共激活因子家族结合，并驱动靶基因的转录活性。ERR和ER基因表达的方式可能显示出共同辅助因子的独立使用。据推测，ERRα的上调可能与卵巢癌的进展有关，而与通过ER调节的辅助因子的可能相互作用无关。尽管ERRα与卵巢癌的生长没有直接关系，但ERRα是卵巢癌预后因素的一个候选者。
