Duffy K N, Duffy C M, Gladman D D
University of Toronto Rheumatic Disease Unit, Women's College Hospital, Toronto, ON, Canada.
J Rheumatol. 1991 Aug;18(8):1180-4.
Infection is a major cause of morbidity and mortality in systemic lupus erythematosus (SLE). A review of all SLE admissions to our hospital during a 5-year period was conducted to determine the rate and nature of infection, and its association with overall disease activity, measured by the SLE Disease Activity Index (SLEDAI). Eighty-one patients (79 women, 2 men) were admitted for a total of 2,738 days (176 admissions). There were 53 proven infections, giving an infection rate of 1.94/100 hospital days. Twenty-three (43.4%) of these were major infections (requiring IV antibiotics). Two of 3 deaths were due to septicemia. By logistic regression analysis, infection was significantly associated with disease activity (p = 0.005), but not with disease duration or prednisone dosage. Our data confirm that infection is common in hospitalized patients with SLE, is associated with overall disease activity independent of prednisone dose, and causes significant mortality. These facts should be borne in mind when hospitalization is considered for patients with SLE.
感染是系统性红斑狼疮（SLE）患者发病和死亡的主要原因。我们对我院5年内所有SLE住院患者进行了回顾性研究，以确定感染的发生率、性质及其与通过SLE疾病活动指数（SLEDAI）衡量的整体疾病活动度之间的关系。81例患者（79名女性，2名男性）共住院2738天（176次入院）。确诊感染53例，感染率为1.94/100住院日。其中23例（43.4%）为严重感染（需要静脉使用抗生素）。3例死亡中有2例死于败血症。通过逻辑回归分析，感染与疾病活动度显著相关（p = 0.005），但与疾病持续时间或泼尼松剂量无关。我们的数据证实，SLE住院患者中感染很常见，与整体疾病活动度相关，与泼尼松剂量无关，并导致显著的死亡率。在考虑SLE患者住院时应牢记这些事实。
