Kaneko Yuko, Suwa Akira, Ikeda Yasuo, Hirakata Michito
Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Mod Rheumatol. 2006;16(1):36-8. doi: 10.1007/s10165-005-0443-5.
Low-dose methotrexate (MTX) therapy is widely used for rheumatoid arthritis (RA) because of its favorable efficacy and toxicity profile. Although Pneumocystis jiroveci pneumonia (PCP) is most often seen in severely immunosuppressed patients, PCP complicating low-dose MTX therapy for RA has been reported to sometimes occur. We herein report two cases of patients who developed PCP during treatment with low-dose MTX, and discuss the importance of prophylaxis for this opportunistic infection.
低剂量甲氨蝶呤（MTX）疗法因其良好的疗效和毒性特征而被广泛用于治疗类风湿性关节炎（RA）。尽管耶氏肺孢子菌肺炎（PCP）最常见于严重免疫抑制的患者，但据报道，低剂量MTX治疗RA时并发PCP的情况有时也会发生。我们在此报告两例在低剂量MTX治疗期间发生PCP的患者，并讨论预防这种机会性感染的重要性。
