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在澳大利亚北部原住民社区中普遍存在的系统发育上不同的金黄色葡萄球菌谱系。

Phylogenetically distinct Staphylococcus aureus lineage prevalent among indigenous communities in northern Australia.

作者信息

Ng Jacklyn W S, Holt Deborah C, Lilliebridge Rachael A, Stephens Alex J, Huygens Flavia, Tong Steven Y C, Currie Bart J, Giffard Philip M

机构信息

Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.

出版信息

J Clin Microbiol. 2009 Jul;47(7):2295-300. doi: 10.1128/JCM.00122-09. Epub 2009 May 6.

DOI:10.1128/JCM.00122-09
PMID:19420161
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2708510/
Abstract

The aim was to determine the evolutionary position of the Staphylococcus aureus clonal complex 75 (CC75) that is prevalent in tropical northern Australia. Sequencing of gap, rpoB, sodA, tuf, and hsp60 and the multilocus sequence typing loci revealed a clear separation between conventional S. aureus and CC75 and significant diversity within CC75.

摘要

目的是确定在澳大利亚北部热带地区流行的金黄色葡萄球菌克隆复合体75（CC75）的进化位置。对gap、rpoB、sodA、tuf和hsp60以及多位点序列分型位点进行测序，结果显示传统金黄色葡萄球菌与CC75之间存在明显差异，且CC75内部存在显著多样性。

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本文引用的文献

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Community-associated strains of methicillin-resistant Staphylococcus aureus and methicillin-susceptible S. aureus in indigenous Northern Australia: epidemiology and outcomes.澳大利亚北部原住民社区中耐甲氧西林金黄色葡萄球菌和甲氧西林敏感金黄色葡萄球菌菌株：流行病学与转归
J Infect Dis. 2009 May 15;199(10):1461-70. doi: 10.1086/598218.
2
Genetic classification and distinguishing of Staphylococcus species based on different partial gap, 16S rRNA, hsp60, rpoB, sodA, and tuf gene sequences.基于不同的部分gap、16S rRNA、hsp60、rpoB、sodA和tuf基因序列对葡萄球菌属进行基因分类和鉴别
J Clin Microbiol. 2008 Mar;46(3):1019-25. doi: 10.1128/JCM.02058-07. Epub 2008 Jan 3.
3
Subtle genetic changes enhance virulence of methicillin resistant and sensitive Staphylococcus aureus.细微的基因变化增强了耐甲氧西林金黄色葡萄球菌和甲氧西林敏感金黄色葡萄球菌的毒力。
BMC Microbiol. 2007 Nov 6;7:99. doi: 10.1186/1471-2180-7-99.
4
Molecular correlates of host specialization in Staphylococcus aureus.金黄色葡萄球菌宿主特异性的分子关联
PLoS One. 2007 Oct 31;2(10):e1120. doi: 10.1371/journal.pone.0001120.
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Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.突变的反应调节因子graR负责金黄色葡萄球菌从异质性万古霉素中介耐药性转变为万古霉素中介耐药性。
Antimicrob Agents Chemother. 2008 Jan;52(1):45-53. doi: 10.1128/AAC.00534-07. Epub 2007 Oct 22.
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MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0.MEGA4：分子进化遗传学分析（MEGA）软件版本4.0。
Mol Biol Evol. 2007 Aug;24(8):1596-9. doi: 10.1093/molbev/msm092. Epub 2007 May 7.
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Use of a single-nucleotide polymorphism genotyping system to demonstrate the unique epidemiology of methicillin-resistant Staphylococcus aureus in remote aboriginal communities.使用单核苷酸多态性基因分型系统来证明耐甲氧西林金黄色葡萄球菌在偏远原住民社区中的独特流行病学情况。
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