代谢综合征的家族聚集性：德黑兰血脂与血糖研究。

Familial aggregation of the metabolic syndrome: Tehran Lipid and Glucose Study.

作者信息

Azizi Fereidoun, Farahani Zeinab Kishani, Ghanbarian Arash, Sheikholeslami Farhad, Mirmiran Parvin, Momenan Amir Abbas, Asl Saleh Zahedi, Hadaegh Farzad, Eskandari Fateme

机构信息

Endocrine Research Center, Shahid Beheshti University (M.C.), Tehran, I.R. Iran.

出版信息

Ann Nutr Metab. 2009;54(3):189-96. doi: 10.1159/000217816. Epub 2009 May 6.

DOI:10.1159/000217816

PMID:19420912

Abstract

AIMS

Familial aggregation of the metabolic syndrome has been reported in some nations. The aim of this study was to evaluate familial aggregation of the metabolic syndrome in Tehranian families.

METHODS

In a cross-sectional study, anthropometry, blood pressure and biochemical data were collected for 4,558 individuals in the Tehran Lipid and Glucose Study. Variables of the metabolic syndrome in offspring were correlated with those of their parents.

RESULTS

There were 1,274 fathers, 1,576 mothers, 802 sons and 906 daughters. Prevalence of metabolic syndrome was 24.4% for fathers, 39.7% for mothers, 9.0% for sons and 7.6% for daughters. Triglycerides and HDL-C of children whose fathers had metabolic syndrome, and BMI, triglycerides and HDL-C of those whose mothers had it were significantly different from those adolescents whose parents were free of metabolic syndrome. Compared with children whose parents did not have metabolic syndrome, the odds ratio (confidence interval) for children with both parents having metabolic syndrome was 4.53 (2.42-8.8) for metabolic syndrome, 2.22 (1.17-4.19) for abdominal obesity, 1.90 (1.15-3.13) for high blood pressure, 2.66 (1.77-4.00) for low HDL-C and 3.16 (2.10-4.75) for high triglyceride levels.

CONCLUSION

This survey provides evidence suggesting that there is a familial aggregation of the metabolic syndrome among Iranian families.

摘要

目的

一些国家已报道代谢综合征存在家族聚集性。本研究旨在评估德黑兰家庭中代谢综合征的家族聚集性。

方法

在一项横断面研究中，收集了德黑兰脂质与葡萄糖研究中4558名个体的人体测量数据、血压和生化数据。将后代代谢综合征的变量与其父母的变量进行关联分析。

结果

研究对象包括1274名父亲、1576名母亲、802名儿子和906名女儿。父亲的代谢综合征患病率为24.4%，母亲为39.7%，儿子为9.0%，女儿为7.6%。父亲患有代谢综合征的儿童的甘油三酯和高密度脂蛋白胆固醇，以及母亲患有代谢综合征的儿童的体重指数、甘油三酯和高密度脂蛋白胆固醇，与父母无代谢综合征的青少年有显著差异。与父母无代谢综合征的儿童相比，父母均患有代谢综合征的儿童患代谢综合征的比值比（置信区间）为4.53（2.42 - 8.8），腹部肥胖为2.22（1.17 - 4.19），高血压为1.90（1.15 - 3.13），低高密度脂蛋白胆固醇为2.66（1.77 - 4.00），高甘油三酯水平为3.16（2.10 - 4.75）。