Svetlov Stanislav I, Larner Stephen F, Kirk Daniel R, Atkinson Joseph, Hayes Ronald L, Wang Kevin K W
Center of Innovative Research, Banyan Biomarkers, Inc. 12085 Research Drive, Alachua, FL 32615, USA.
J Neurotrauma. 2009 Jun;26(6):913-21. doi: 10.1089/neu.2008.0609.
The nature of warfare in the 21st century has led to a significant increase in primary blast or over-pressurization injuries to the whole body and head, which manifest as a complex of neuro-somatic damage, including traumatic brain injury (TBI). Identifying relevant pathogenic pathways in reproducible experimental models of primary blast wave exposure is therefore vital to the development of biomarkers for diagnostics of blast brain injury. Comparative analysis of mechanisms and putative biomarkers of blast brain injury is complicated by a deficiency of experimental studies. In this article, we present an overview of current TBI biomarkers, as well as outline experimental strategies to investigate molecular signatures of blast neurotrauma and to develop a pathway network map for novel biomarker discovery. These biomarkers will be effective for triaging and managing both combat and civilian casualities.
21世纪的战争性质导致全身和头部原发性爆炸或超压损伤显著增加，这些损伤表现为包括创伤性脑损伤（TBI）在内的神经-躯体损伤复合体。因此，在可重复的原发性爆炸波暴露实验模型中识别相关致病途径对于开发用于诊断爆炸脑损伤的生物标志物至关重要。由于实验研究的缺乏，对爆炸脑损伤的机制和假定生物标志物进行比较分析变得复杂。在本文中，我们概述了当前的TBI生物标志物，并概述了研究爆炸神经创伤分子特征以及开发用于发现新型生物标志物的通路网络图的实验策略。这些生物标志物将有效地用于对战时和民用伤员的分类和管理。
