在进展为猴艾滋病的过程中，猿猴免疫缺陷病毒env基因的变异局限于V1和V4区域。
Variation in simian immunodeficiency virus env is confined to V1 and V4 during progression to simian AIDS.
作者信息
Overbaugh J, Rudensey L M, Papenhausen M D, Benveniste R E, Morton W R
机构信息
Department of Microbiology, University of Washington, Seattle 98195.
出版信息
J Virol. 1991 Dec;65(12):7025-31. doi: 10.1128/JVI.65.12.7025-7031.1991.
Abstract
We have monitored changes in the simian immunodeficiency virus (SIV) envelope (env) gene in two macaques which developed AIDS after inoculation with a molecular clone of SIV. As the animals progressed to AIDS, selection occurred for viruses with variation in two discrete regions (V1 and V4) but not for viruses with changes in the region of SIV env that corresponds to the immunodominant, V3 loop of human immunodeficiency virus. Within the highly variable domains, the vast majority of nucleotide changes encoded an amino acid change (98%), suggesting that these envelope variants had evolved as a result of phenotypic selection. Analysis of the biological properties of these variants, which have been selected for in the host, may be useful in defining the mechanisms underlying viral persistence and progression to simian AIDS.
摘要
我们监测了两只接种了猿猴免疫缺陷病毒（SIV）分子克隆后患上艾滋病的猕猴体内SIV包膜（env）基因的变化。随着这些动物病情发展至艾滋病阶段，出现了对在两个离散区域（V1和V4）发生变异的病毒的选择，但对于在与人类免疫缺陷病毒免疫显性V3环相对应的SIV env区域发生变化的病毒则未出现选择。在高度可变区，绝大多数核苷酸变化都编码了氨基酸变化（98%），这表明这些包膜变体是表型选择的结果。对这些在宿主体内被选择出来的变体的生物学特性进行分析，可能有助于确定病毒持续存在及发展为猿猴艾滋病的潜在机制。
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