Vascular Biology Unit, School of Medicine, James Cook University, Townsville, QLD 4811, Australia.
Curr Genomics. 2008 Mar;9(1):29-42. doi: 10.2174/138920208783884856.
A family history of atherosclerosis is independently associated with an increased incidence of cardiovascular events. The genetic factors underlying the importance of inheritance in atherosclerosis are starting to be understood. Genetic variation, such as mutations or common polymorphisms has been shown to be involved in modulation of a range of risk factors, such as plasma lipoprotein levels, inflammation and vascular calcification. This review presents examples of present studies of the role of genetic polymorphism in atherosclerosis.
家族性动脉粥样硬化病史与心血管事件的发生率增加独立相关。导致动脉粥样硬化遗传重要性的遗传因素开始被人们所理解。遗传变异，如突变或常见的多态性，已被证明参与调节一系列风险因素，如血浆脂蛋白水平、炎症和血管钙化。本文介绍了目前研究遗传多态性在动脉粥样硬化中作用的一些实例。
