一项大型全县范围的学校流感免疫运动的有效性证据。
Evidence of effectiveness from a large county-wide school-based influenza immunization campaign.
作者信息
Grijalva Carlos G, Zhu Yuwei, Griffin Marie R
机构信息
Department of Preventive Medicine, Vanderbilt University School of Medicine, 1500 21st Avenue Suite 2600, The Village at Vanderbilt, Nashville, TN 37232-2637, United States.
出版信息
Vaccine. 2009 May 5;27(20):2633-6. doi: 10.1016/j.vaccine.2009.02.039. Epub 2009 Feb 24.
Abstract
A school-based campaign in Knox County, TN immunized 41% and 48% of school children with live attenuated influenza vaccine in 2005 and 2006, respectively. We computed the relative risk (RR) of a positive rapid influenza test in Knox compared to Knox-surrounding county children (controls) during five baseline and two campaign seasons. Among children aged <5 years, the RR for a positive test remained relatively constant throughout the study seasons. Among children aged 5-17 years (target population), the RR was 1 during baseline and declined by 21% (RR, 0.79; 95% CI, 0.59-1.05) and 27% (RR, 0.73; 95% CI, 0.60-0.87) during the first and second campaign season, respectively. These findings suggest a direct beneficial effect of the immunization campaign.
摘要
田纳西州诺克斯县开展的一项校园疫苗接种活动，在2005年和2006年分别为41%和48%的学童接种了减毒活流感疫苗。我们计算了在五个基线期和两个活动期内，诺克斯县儿童与周边县儿童（对照组）进行快速流感检测呈阳性的相对风险（RR）。在5岁以下儿童中，整个研究期间检测呈阳性的RR保持相对稳定。在5至17岁的儿童（目标人群）中，基线期RR为1，在第一个和第二个活动期分别下降了21%（RR，0.79；95%CI，0.59 - 1.05）和27%（RR，0.73；95%CI，0.60 - 0.87）。这些发现表明疫苗接种活动具有直接的有益效果。
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