Maldini M, Sosa S, Montoro P, Giangaspero A, Balick M J, Pizza C, Della Loggia R
Department of Pharmaceutical Science, University of Salerno, via Ponte don Melillo, Fisciano, Sa, Italy.
J Ethnopharmacol. 2009 Apr 21;122(3):430-3. doi: 10.1016/j.jep.2009.02.002. Epub 2009 Feb 11.
An investigation of topical anti-inflammatory activity was undertaken on plants used in Central America traditional medicine.
Four herbal drugs used in the folk medicine of Central America to treat inflammatory skin affections (Acacia cornigera bark, Byrsonima crassifolia bark, Sphagneticola trilobata leaves and Sweetia panamensis bark) were evaluated for their topical anti-inflammatory activity.
Petroleum ether, chloroform and methanol extracts were obtained for herbal medicines and then extracts were tested on Croton oil-induced ear dermatitis model in mice.
Almost all the extracts reduced the Croton oil-induced ear dermatitis in mice and the chloroform ones showed the highest activity, with ID(50) (dose giving 50% oedema inhibition) values ranging from 112 microg/cm(2) (Byrsonima crassifolia) to 183 microg/cm(2) (Sphagneticola trilobata). As reference, ID(50) of the non-steroidal anti-inflammatory drug indomethacin was 93 microg/cm(2).
Lipophilic extracts from these species can be regarded as potential sources of anti-inflammatory principles.
对中美洲传统医学中使用的植物进行了局部抗炎活性研究。
评估了中美洲民间医学中用于治疗炎症性皮肤病的四种草药（牛角相思树皮、厚叶腺背蓝树皮、三裂叶蟛蜞菊叶和巴拿马甜树皮）的局部抗炎活性。
获得了草药的石油醚、氯仿和甲醇提取物，然后在小鼠巴豆油诱导的耳部皮炎模型上对提取物进行测试。
几乎所有提取物都减轻了小鼠巴豆油诱导的耳部皮炎，氯仿提取物显示出最高活性，半数抑制剂量（ID(50)）值范围为112微克/平方厘米（厚叶腺背蓝）至183微克/平方厘米（三裂叶蟛蜞菊）。作为对照，非甾体抗炎药吲哚美辛的ID(50)为93微克/平方厘米。
这些物种的亲脂性提取物可被视为抗炎成分的潜在来源。
