Faculdade de Ciências Farmacêuticas, Universidade Federal do Amazonas, Rua Alexandre Amorim, 330, Aparecida, 69910-300, Manaus, Amazonas, Brazil.
J Ethnopharmacol. 2012 Mar 27;140(2):282-6. doi: 10.1016/j.jep.2012.01.018. Epub 2012 Jan 21.
Decoctions or infusions of the stem bark of Byrsonima japurensis A. Juss. (Malpighiaceae) are widely used as an anti-inflammatory drug in folk medicine of Amazonas State (Brazil).
To evaluate the pharmacological potential of an aqueous extract of the stem bark of Byrsonima japurensis (BJEA) to scientifically verify of its traditional use.
Anti-inflammatory, antihyperalgesic and antiulcer activities were evaluated in Wistar rats, a Hippocratic screening was performed in Swiss mice to evaluate the toxic effects, and antiplatelet evaluation was performed in human platelet rich plasma assay. Additionally, antioxidant activity was evaluated by superoxide radical scavenging method and β-carotene bleaching test.
Anti-inflammatory, antihyperalgesic and gastroprotective activities were observed in rats treated orally with different doses of BJEA. While signals of toxicity were observed in the mice treated with a very high dose of extract (5000mg/kg), no death occurred. BJEA also showed expressive antiplatelet and antioxidant activities in vitro.
According to our results, it was concluded that stem bark of Byrsonima japurensis has significant and safe anti-inflammatory activity, which is closely related with their potent antioxidant activity, supporting the folk medicinal use of this species.
产自亚马孙州（巴西）的野苹果（Malpighiaceae）的茎皮煎剂或浸剂在民间医学中被广泛用作抗炎药。
评估野苹果（BJEA）茎皮水提取物的药理学潜力，以科学验证其传统用途。
在 Wistar 大鼠中评估抗炎、抗痛觉过敏和抗溃疡活性，在瑞士小鼠中进行希波克拉底筛选以评估毒性作用，并在富含人血小板的血浆测定中评估抗血小板作用。此外，通过超氧自由基清除法和β-胡萝卜素漂白试验评估抗氧化活性。
BJEA 经口服给予不同剂量的大鼠后，表现出抗炎、抗痛觉过敏和胃保护活性。虽然在给予非常高剂量提取物（5000mg/kg）的小鼠中观察到毒性信号，但没有死亡发生。BJEA 还在体外表现出明显的抗血小板和抗氧化活性。
根据我们的结果，可以得出结论，野苹果的茎皮具有显著且安全的抗炎活性，这与其强大的抗氧化活性密切相关，支持了该物种的民间药用用途。
