Gutiérrez Rosa Martha Pérez, Ramirez Alethia Muñiz
Research Laboratory of Natural Products, School of Chemical Engineering and Extractive Industries-IPN, Unidad Profesional Adolfo Lopez Mateos, Zacatenco, D.F. CP 07758 Mexico.
2Department of Biotechnology and Bioengineering, Cinvestav-IPN, Av. IPN 2508, Col. San Pedro Zacatenco, D.F. CP07360 Mexico.
Food Sci Biotechnol. 2016 Aug 31;25(4):1135-1145. doi: 10.1007/s10068-016-0182-8. eCollection 2016.
The novel dimeric guaianolides sesquiterpene lactone Byrsoninas A and B from seed hexane extract of were identified. Streptozotocin-induced mildly diabetic and severely diabetic mice were treated with these oral administrations at a dosage of 20 mg/kg of body weight per day for 30 days. Also the protective effect in RIN-5F cells against oxidative stress was investigated and TNF-α and IL-6 levels were measured. Both Byrsonina types reduced blood glucose, cholesterol, triglyceride, lipoprotein, and transaminase levels and increased HDL-cholesterol, antioxidant enzymes, and TBARS-reactive substance levels. Byrsoninas A and B both improved this glucose metabolism by reducing insulin resistance and by stimulating insulin production due to protection effect for pancreatic β-cells against oxidative stress, lipid abnormalities were reduced and, chronic inflammation responses were alleviated producing a hepatoprotective role.
从[植物名称]种子己烷提取物中鉴定出新型二聚愈创木内酯倍半萜内酯Byrsoninas A和B。链脲佐菌素诱导的轻度糖尿病和重度糖尿病小鼠每天以20 mg/kg体重的剂量口服给予这些物质，持续30天。此外，还研究了其对RIN-5F细胞氧化应激损伤的保护作用，并检测了肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）水平。两种Byrsonina类型均降低了血糖、胆固醇、甘油三酯、脂蛋白和转氨酶水平，并提高了高密度脂蛋白胆固醇、抗氧化酶和硫代巴比妥酸反应物水平。Byrsoninas A和B均通过降低胰岛素抵抗和刺激胰岛素分泌来改善葡萄糖代谢，这归因于其对胰腺β细胞氧化应激损伤的保护作用，减少了脂质异常，并减轻了慢性炎症反应，发挥了肝脏保护作用。
